| Gene Information | |
|---|---|
| Gene Name | SLC44A4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 710 |
| Protein Names | Choline transporter-like protein 4 (Solute carrier family 44 member 4) (Thiamine pyrophosphate transporter 1) (hTPPT1) |
| Target Name | choline transporter-like protein 4 |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000204385 ) 3 ( ENSG00000206378 ) 3 ( ENSG00000228263 ) 3 ( ENSG00000229077 ) 3 ( ENSG00000231479 ) 3 ( ENSG00000232180 ) 3 ( ENSG00000235336 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q53GD3 |
| Gene Card | SLC44A4 |
| Uniprot ID | Q53GD3 |
| Pfam | PF04515 |
| In ASD | no |
| Allosteric Prediction | no (-0.381731987) |
| Ortholog in Animals | Alpaca_ SLC44A4 ( ortholog_one2one ) Dog_ SLC44A4 ( ortholog_one2one ) GuineaPig_ SLC44A4 ( ortholog_one2one ) Macaque_ SLC44A4 ( ortholog_one2one ) Mouse_ Slc44a4 ( ortholog_one2one ) Pig_ SLC44A4 ( ortholog_one2one ) Rat_ Slc44a4 ( ortholog_one2one ) Rabbit_ SLC44A4 ( ortholog_one2one ) |
| Ohnologs | SLC44A2, SLC44A5 |
| Paralogs | SLC44A2, SLC44A1, SLC44A5, SLC44A3 |
| Tissue | prostate, stomach, transverse.colon |
| Tissue Specificity | Highly expressed in colon, also detected in prostate, trachea and lung (PubMed:24379411). Isoform 3 is also expressed in colon but a lower levels (PubMed:24379411). {ECO:0000269|PubMed:24379411}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2075798 rs12661281 rs17856465 rs1135402753 rs2242665 rs644827 rs116706632 rs563426936 rs6915800 |
| Subcellular location [CC] | Membrane {ECO:0000269|PubMed:24379411, ECO:0000269|PubMed:26828122}; Multi-pass membrane protein {ECO:0000305|PubMed:24379411, ECO:0000305|PubMed:26828122}. Apical cell membrane {ECO:0000269|PubMed:24379411}. |
| Mouse PG classification | NA |
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