Gene Information
Gene NamePAK2
OrganismHomo sapiens (Human)
Gene Length524
Protein NamesSerine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)]
Target Nameserine/threonine-protein kinase pak 2
Target TypeNA
Gene Age1714 ( ENSG00000180370 )
Evolutionary StageEukaryota
AlphaFoldDBQ13177
Gene CardPAK2
Uniprot IDQ13177
PfamPF00786; PF00069
In ASDyes
Allosteric Predictionyes (1.000120014)
Ortholog in AnimalsAlpaca_ PAK2 ( ortholog_one2one )
Dog_ PAK2 ( ortholog_one2one )
GuineaPig_ PAK2 ( ortholog_one2one )
Macaque_ PAK2 ( ortholog_one2one )
Mouse_ Pak2 ( ortholog_one2one )
Pig_ PAK2 ( ortholog_one2one )
Rat_ Pak2 ( ortholog_one2one )
Rabbit_ PAK2 ( ortholog_one2one )
OhnologsPAK3, PAK1
ParalogsPAK5, PAK6, PAK4, SBK2, STK39, MAP4K1, MINK1, TNIK, MAP4K5, SLK, MAP3K14, MAP3K19, STRADB, STK4, MAP3K1, TAOK2, MAP4K3, NRK, STRADA, MAP2K3, STK10, MAP2K6, STK26, TAOK3, TAOK1, MAP3K8, MAP4K2, OXSR1, STK3, NEK4, STK25, STK24, MAP4K4, PAK1, PAK3
TissueNA
Tissue SpecificityUbiquitously expressed. Higher levels seen in skeletal muscle, ovary, thymus and spleen. {ECO:0000269|PubMed:7744004}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.027778(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3PCS  (X-ray  2.86A  ) 
DBSNP NA 
Subcellular location [CC][Serine/threonine-protein kinase PAK 2]: Cytoplasm {ECO:0000269|PubMed:19923322, ECO:0000269|PubMed:21555521}. Nucleus {ECO:0000269|PubMed:12853446, ECO:0000269|PubMed:21555521}. Note=MYO18A mediates the cellular distribution of the PAK2-ARHGEF7-GIT1 complex to the inner surface of the cell membrane. {ECO:0000269|PubMed:19923322}.;
[PAK-2p34]: Nucleus {ECO:0000269|PubMed:12853446}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:15471851}. Membrane {ECO:0000269|PubMed:16617111};
Lipid-anchor {ECO:0000269|PubMed:16617111}. Note=Interaction with ARHGAP10 probably changes PAK-2p34 location to cytoplasmic perinuclear region (PubMed:15471851). Myristoylation changes PAK-2p34 location to the membrane (PubMed:16617111). {ECO:0000269|PubMed:15471851, ECO:0000269|PubMed:16617111}.
Mouse PG classificationNA
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