Gene Information
Gene NameKCNS3
OrganismHomo sapiens (Human)
Gene Length491
Protein NamesPotassium voltage-gated channel subfamily S member 3 (Delayed-rectifier K(+) channel alpha subunit 3) (Voltage-gated potassium channel subunit Kv9.3)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000170745 )
Evolutionary StageVertebrata
AlphaFoldDBQ9BQ31
Gene CardKCNS3
Uniprot IDQ9BQ31
PfamPF02214; PF00520
In ASDno
Allosteric Predictionyes (0.088142448)
Ortholog in AnimalsAlpaca_ KCNS3 ( ortholog_one2one )
Dog_ KCNS3 ( ortholog_one2one )
GuineaPig_ KCNS3 ( ortholog_one2one )
Macaque_ KCNS3 ( ortholog_one2one )
Mouse_ Kcns3 ( ortholog_one2one )
Pig_ KCNS3 ( ortholog_one2one )
Rat_ Kcns3 ( ortholog_one2one )
Rabbit_ KCNS3 ( ortholog_one2one )
OhnologsKCNG1, KCNS1, KCNS2, KCNB1, KCNV1, KCNB2
ParalogsKCNS1, KCND1, KCNA7, KCNB2, KCNG3, KCNQ1, KCNQ3, KCNC4, KCNV1, KCNA1, KCNQ4, KCNA10, KCNC3, KCNV2, KCND3, KCNQ2, KCNB1, KCNA6, KCNA2, KCNA5, KCNG1, KCND2, KCNC1, KCNC2, KCNA4, KCNA3, KCNQ5, KCNF1, KCNG2, KCNG4, KCNS2
TissueNA
Tissue SpecificityDetected in whole normal term placental and placental chorionic plate arteries and veins. Detected in syncytiotrophoblast and in blood vessel endothelium within intermediate villi and chorionic plate (at protein level) (PubMed:22943705). Detected in most tissues, but not in peripheral blood lymphocytes. The highest levels of expression are in lung (PubMed:10484328). {ECO:0000269|PubMed:10484328, ECO:0000269|PubMed:22943705}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs17856097  rs4832524 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:10484328};
Multi-pass membrane protein {ECO:0000305}. Note=May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 (PubMed:10484328). {ECO:0000269|PubMed:10484328}.
Mouse PG classificationNA
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