| Gene Information | |
|---|---|
| Gene Name | GPNMB |
| Organism | Homo sapiens (Human) |
| Gene Length | 572 |
| Protein Names | Transmembrane glycoprotein NMB (Hematopoietic growth factor inducible neurokinin-1 type) |
| Target Name | transmembrane glycoprotein nmb |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000136235 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q14956 |
| Gene Card | GPNMB |
| Uniprot ID | Q14956 |
| Pfam | PF20433; PF00801 |
| In ASD | no |
| Allosteric Prediction | no (-0.15939314) |
| Ortholog in Animals | Alpaca_ GPNMB ( ortholog_one2one ) GuineaPig_ GPNMB ( ortholog_one2one ) Macaque_ GPNMB ( ortholog_one2one ) Mouse_ Gpnmb ( ortholog_one2one ) Pig_ GPNMB ( ortholog_one2one ) Rat_ Gpnmb ( ortholog_one2one ) Rabbit_ GPNMB ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PMEL, TMEM130 |
| Tissue | NA |
| Tissue Specificity | Widely expressed, but very low expression, if any, in the brain (PubMed:12609765, PubMed:16609006). Expressed in the epidermis with higher levels in melanocytes compared with keratinocytes and Langerhans cells (at protein level) (PubMed:29336782). Expressed in peripheral blood, but not bone marrow mononuclear cells (PubMed:12609765). Expressed in tissue macrophages, including liver Kuppfer cells and lung alveolar macrophages, in podocytes and in some cells of the ciliary body of the eye (at protein level) (PubMed:16489096). May be overexpressed in various cancers, including melanoma and glioblastoma multiforme (PubMed:7814155, PubMed:16489096, PubMed:16609006). {ECO:0000269|PubMed:12609765, ECO:0000269|PubMed:16489096, ECO:0000269|PubMed:16609006, ECO:0000269|PubMed:29336782, ECO:0000269|PubMed:7814155}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs755767733 rs530436 rs530413 rs35499907 rs35363287 rs35878037 |
| Subcellular location [CC] | Cell membrane; Single-pass type I membrane protein {ECO:0000269|PubMed:16489096, ECO:0000269|PubMed:16609006}. Melanosome membrane {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}; Single-pass type I membrane protein {ECO:0000305}. Early endosome membrane {ECO:0000269|PubMed:29336782}; Single-pass type I membrane protein {ECO:0000305}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:17081065}. |
| Mouse PG classification | NA |
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