Gene Information
Gene NameSLC5A11
OrganismHomo sapiens (Human)
Gene Length675
Protein NamesSodium/myo-inositol cotransporter 2 (Na(+)/myo-inositol cotransporter 2) (Sodium-dependent glucose cotransporter) (Sodium/glucose cotransporter KST1) (Sodium/myo-inositol transporter 2) (SMIT2) (Solute carrier family 5 member 11)
Target NameNA
Target TypeNA
Gene Age886 ( ENSG00000158865 )
3 ( ENSG00000288216 )
Evolutionary StageEuk+Bac
AlphaFoldDBQ8WWX8
Gene CardSLC5A11
Uniprot IDQ8WWX8
PfamPF00474
In ASDno
Allosteric Predictionno (-0.750594301)
Ortholog in AnimalsAlpaca_ SLC5A11 ( ortholog_one2one )
Dog_ SLC5A11 ( ortholog_one2one )
GuineaPig_ SLC5A11 ( ortholog_one2one )
Macaque_ SLC5A11 ( ortholog_one2one )
Mouse_ Slc5a11 ( ortholog_one2one )
Pig_ SLC5A11 ( ortholog_one2one )
Rat_ Slc5a11 ( ortholog_one2one )
Rabbit_ SLC5A11 ( ortholog_one2one )
OhnologsSLC5A1
ParalogsSLC5A5, SLC5A8, SLC5A1, SLC5A6, SLC5A9, SLC5A3, SLC5A10, SLC5A4, SLC5A2, SLC5A12, SLC5A7
Tissuebrain, duodenum, kidney, small.intestine, substantia.nigra
Tissue SpecificityHighest expression in heart, skeletal muscle, kidney, liver and placenta. Weaker expression in brain, colon, spleen, lung and peripheral blood leukocytes. {ECO:0000269|PubMed:12039040}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs36048966  rs11074656  rs35993597  rs17854935  rs35038575 
Subcellular location [CC]Membrane {ECO:0000305|PubMed:19032932};
Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q9Z1F2};
Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9Z1F2}. Note=Located on apical membrane of enterocytes (By similarity). Located on membrane of kidney brush border membrane vesicles (BBMVs) and apical membrane of proximal convoluted tubules (By similarity). {ECO:0000250|UniProtKB:Q28728, ECO:0000250|UniProtKB:Q9Z1F2}.
Mouse PG classificationNA
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