| Gene Information | |
|---|---|
| Gene Name | ZDHHC17 |
| Organism | Homo sapiens (Human) |
| Gene Length | 632 |
| Protein Names | Palmitoyltransferase ZDHHC17 (EC 2.3.1.225) (Acyltransferase ZDHHC17) (EC 2.3.1.-) (DHHC domain-containing cysteine-rich protein 17) (DHHC17) (Huntingtin yeast partner H) (Huntingtin-interacting protein 14) (HIP-14) (Huntingtin-interacting protein 3) (HIP-3) (Huntingtin-interacting protein H) (Putative MAPK-activating protein PM11) (Putative NF-kappa-B-activating protein 205) (Zinc finger DHHC domain-containing protein 17) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000186908 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8IUH5 |
| Gene Card | ZDHHC17 |
| Uniprot ID | Q8IUH5 |
| Pfam | PF12796; PF01529 |
| In ASD | no |
| Allosteric Prediction | no (-0.912336413) |
| Ortholog in Animals | Alpaca_ ZDHHC17 ( ortholog_one2one ) Dog_ ZDHHC17 ( ortholog_one2one ) GuineaPig_ ZDHHC17 ( ortholog_one2one ) Macaque_ ZDHHC17 ( ortholog_one2one ) Mouse_ Zdhhc17 ( ortholog_one2one ) Pig_ ZDHHC17 ( ortholog_one2one ) Rat_ Zdhhc17 ( ortholog_one2one ) Rabbit_ ZDHHC17 ( ortholog_one2one ) |
| Ohnologs | ZDHHC13 |
| Paralogs | ZDHHC13, ANKRD35 |
| Tissue | NA |
| Tissue Specificity | Expressed in all brain regions. Expression is highest in the cortex, cerebellum, occipital lobe and caudate and lowest in the spinal cord. Expression is also seen in testis, pancreas, heart and kidney. {ECO:0000269|PubMed:12393793}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3EU9 (X-ray 1.99A ) 5W7I (X-ray 2.10A ) 5W7J (X-ray 2.20A ) |
| DBSNP | rs33996476 |
| Subcellular location [CC] | Golgi apparatus membrane {ECO:0000269|PubMed:15603740, ECO:0000269|PubMed:18794299}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:18794299}; Multi-pass membrane protein {ECO:0000255}. Presynaptic cell membrane {ECO:0000269|PubMed:18032660}; Multi-pass membrane protein {ECO:0000255}. Note=Low extracellular Mg(2+) induces increase in Golgi and in post-Golgi membrane vesicles. {ECO:0000269|PubMed:18794299}. |
| Mouse PG classification | NA |
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