| Gene Information | |
|---|---|
| Gene Name | SLC22A3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 556 |
| Protein Names | Solute carrier family 22 member 3 (Extraneuronal monoamine transporter) (EMT) (Organic cation transporter 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000146477 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | O75751 |
| Gene Card | SLC22A3 |
| Uniprot ID | O75751 |
| Pfam | PF07690 |
| In ASD | no |
| Allosteric Prediction | yes (0.068041481) |
| Ortholog in Animals | Alpaca_ SLC22A3 ( ortholog_one2one ) Dog_ SLC22A3 ( ortholog_one2one ) GuineaPig_ SLC22A3 ( ortholog_one2one ) Macaque_ SLC22A3 ( ortholog_one2one ) Mouse_ Slc22a3 ( ortholog_one2one ) Pig_ SLC22A3 ( ortholog_one2one ) Rat_ Slc22a3 ( ortholog_one2one ) Rabbit_ SLC22A3 ( ortholog_one2one ) |
| Ohnologs | SLC22A8, SLC22A11, SLC22A25, SLC22A6, SLC22A13 |
| Paralogs | SLC22A24, SLC22A12, SLC22A1, SLC22A6, SVOP, SLC22A17, SLC22A7, SLC22A11, SLC22A23, SLC22A2, SLC22A25, SLC22A15, SLC22A9, SLC22A4, SLC22A5, SLC22A16, SLC22A8, SVOPL, SLC22A31, SLC22A13, SLC22A14, SLC22A10 |
| Tissue | NA |
| Tissue Specificity | Expressed in placenta, skeletal muscle, prostate, aorta, liver, fetal lung, salivary gland, adrenal gland, kidney and brain cortex. No expression detected in spleen. {ECO:0000269|PubMed:10196521, ECO:0000269|PubMed:10966924, ECO:0000269|PubMed:9933568}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs8187715 rs8187717 |
| Subcellular location [CC] | Membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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