| Gene Information | |
|---|---|
| Gene Name | UNQ602/PRO1188 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1184 |
| Protein Names | Cartilage intermediate layer protein 1 (CILP-1) (Cartilage intermediate-layer protein) [Cleaved into: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | O75339 |
| Gene Card | CILP |
| Uniprot ID | O75339 |
| Pfam | PF13330; PF00090 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Specifically expressed in cartilage. Localizes in the intermediates layer of articular cartilage but neither in the superficial nor in the deepest regions. Specifically and highly expressed in intervertebral disk tissue. Expression increases with aging in hip articular cartilage. Overexpressed in articular hyaline cartilage from patients with calcium pyrophosphate dihydrate crystal deposition disease (CPPD). Expression in intervertebral disk tissue from individuals with lumbar disk disease increases as disk degeneration progresses. {ECO:0000269|PubMed:12483726, ECO:0000269|PubMed:15864306, ECO:0000269|PubMed:9722583, ECO:0000269|PubMed:9722584}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2585033 rs2073711 rs149286218 rs2679118 rs771628304 rs2679117 rs768702821 rs769023414 rs938952 rs747702148 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:15864306}. |
| Mouse PG classification | NA |
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