| Gene Information | |
|---|---|
| Gene Name | INMT |
| Organism | Homo sapiens (Human) |
| Gene Length | 263 |
| Protein Names | Indolethylamine N-methyltransferase (Indolamine N-methyltransferase) (EC 2.1.1.49) (EC 2.1.1.96) (Aromatic alkylamine N-methyltransferase) (Amine N-methyltransferase) (Arylamine N-methyltransferase) (Thioether S-methyltransferase) (TEMT) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000241644 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O95050 |
| Gene Card | INMT |
| Uniprot ID | O95050 |
| Pfam | PF01234 |
| In ASD | no |
| Allosteric Prediction | no (-0.722206401) |
| Ortholog in Animals | Alpaca_ INMT ( ortholog_one2one ) Macaque_ INMT ( ortholog_one2one ) Mouse_ Inmt ( ortholog_one2one ) Pig_ INMT ( ortholog_one2one ) Rat_ Inmt ( ortholog_one2one ) Rabbit_ INMT ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PNMT, NNMT |
| Tissue | NA |
| Tissue Specificity | Widely expressed. The highest levels were in thyroid, adrenal gland, adult and fetal lung. Intermediate levels in heart, placenta, skeletal muscle, testis, small intestine, pancreas, stomach, spinal cord, lymph node and trachea. Very low levels in adult and fetal kidney and liver, in adult spleen, thymus, ovary, colon and bone marrow. Not expressed in peripheral blood leukocytes and brain. {ECO:0000269|PubMed:10552930}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2A14 (X-ray 1.70A ) |
| DBSNP | rs4723010 rs2302339 rs56800285 rs2302340 rs6970210 rs4720015 rs6970605 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. |
| Mouse PG classification | NA |
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