Gene Information
Gene NameTEPSIN
OrganismHomo sapiens (Human)
Gene Length525
Protein NamesAP-4 complex accessory subunit Tepsin (ENTH domain-containing protein 2) (Epsin for AP-4) (Tetra-epsin)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000167302 )
Evolutionary StageEukaryota
AlphaFoldDBQ96N21
Gene CardTEPSIN
Uniprot IDQ96N21
PfamPF01417
In ASDno
Allosteric Predictionno (-1.317050842)
Ortholog in AnimalsAlpaca_ TEPSIN ( ortholog_one2one )
Dog_ TEPSIN ( ortholog_one2one )
GuineaPig_ TEPSIN ( ortholog_one2one )
Macaque_ TEPSIN ( ortholog_one2one )
Mouse_ Tepsin ( ortholog_one2one )
Pig_ TEPSIN ( ortholog_one2one )
Rat_ Tepsin ( ortholog_one2one )
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 5WF9  (X-ray  1.80A  5WFB  (X-ray  1.38A 
DBSNP NA 
Subcellular location [CC]Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:26542808, ECO:0000269|PubMed:26756312};
Peripheral membrane protein {ECO:0000269|PubMed:26756312}. Cytoplasmic vesicle {ECO:0000269|PubMed:22472443}. Cytoplasm, cytosol {ECO:0000269|PubMed:22472443}. Note=Extensively colocalizes with AP-4 which mediates the recruitment of TEPSIN to the trans-Golgi network. {ECO:0000269|PubMed:22472443, ECO:0000269|PubMed:26542808}.
Mouse PG classificationNA
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