Gene Information
Gene NameCDC42BPB
OrganismHomo sapiens (Human)
Gene Length1711
Protein NamesSerine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta)
Target NameNA
Target TypeNA
Gene Age987 ( ENSG00000198752 )
Evolutionary StageOpisthokonta
AlphaFoldDBQ9Y5S2
Gene CardCDC42BPB
Uniprot IDQ9Y5S2
PfamPF00130; PF00780; PF08826; PF15796; PF00069
In ASDno
Allosteric Predictionno (-0.47205511)
Ortholog in AnimalsAlpaca_ CDC42BPB ( ortholog_one2one )
Dog_ CDC42BPB ( ortholog_one2one )
GuineaPig_ CDC42BPB ( ortholog_one2one )
Macaque_ CDC42BPB ( ortholog_one2one )
Mouse_ Cdc42bpb ( ortholog_one2one )
Pig_ CDC42BPB ( ortholog_one2one )
Rat_ Cdc42bpb ( ortholog_one2one )
Rabbit_ CDC42BPB ( ortholog_one2one )
OhnologsCDC42BPA, CDC42BPG
ParalogsCDC42BPG, CDC42BPA, CIT, ROCK1, ROCK2
TissueNA
Tissue SpecificityExpressed in all tissues examined, with high levels in heart, brain, placenta and lung. {ECO:0000269|PubMed:10198171}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3QFV  (X-ray  2.65A  )  3TKU  (X-ray  2.15A  )  4UAK  (X-ray  1.73A  )  4UAL  (X-ray  1.71A  )  5OTE  (X-ray  1.68A  )  5OTF  (X-ray  2.00A  ) 
DBSNP rs1158962067  rs36001612  rs55948035  rs1595472741  rs34822377  rs146298297  rs56412851 
Subcellular location [CC]Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:21240187};
Peripheral membrane protein {ECO:0000269|PubMed:21240187};
Cytoplasmic side {ECO:0000269|PubMed:21240187}. Cell junction {ECO:0000269|PubMed:21240187}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q3UU96}. Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent (By similarity). Detected at the leading edge of migrating cells. Localization at the leading edge of migrating cells requires interaction with catalytically active CDC42 (PubMed:21240187). Localizes in the lamellipodium in a FAM89B/LRAP25-dependent manner (By similarity). {ECO:0000250|UniProtKB:O54874, ECO:0000250|UniProtKB:Q3UU96, ECO:0000269|PubMed:21240187}.
Mouse PG classificationNA
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