| Gene Information | |
|---|---|
| Gene Name | TGFBR2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 567 |
| Protein Names | TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II) |
| Target Name | tgf-beta receptor type ii |
| Target Type | Clinical trial target |
| Gene Age | 987 ( ENSG00000163513 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P37173 |
| Gene Card | TGFBR2 |
| Uniprot ID | P37173 |
| Pfam | PF08917; PF07714 |
| In ASD | no |
| Allosteric Prediction | yes (1.447249698) |
| Ortholog in Animals | Alpaca_ TGFBR2 ( ortholog_one2one ) Dog_ TGFBR2 ( ortholog_one2one ) GuineaPig_ TGFBR2 ( ortholog_one2one ) Macaque_ TGFBR2 ( ortholog_one2one ) Mouse_ Tgfbr2 ( ortholog_one2one ) Pig_ TGFBR2 ( ortholog_one2one ) Rat_ Tgfbr2 ( ortholog_one2one ) Rabbit_ TGFBR2 ( ortholog_one2one ) |
| Ohnologs | ACVR2A |
| Paralogs | ACVR1, BMPR2, ACVR2A, ACVR2B, TGFBR1, BMPR1A, AMHR2, ACVR1B, BMPR1B, ACVRL1, ACVR1C |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002657(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1KTZ (X-ray 2.15A ) 1M9Z (X-ray 1.05A ) 1PLO (NMR - ) 2PJY (X-ray 3.00A ) 3KFD (X-ray 3.00A ) 4P7U (X-ray 1.50A ) 4XJJ (X-ray 1.40A ) 5E8V (X-ray 1.69A ) 5E8Y (X-ray 2.05A ) 5E91 (X-ray 2.42A ) 5E92 (X-ray 2.08A ) 5QIN (X-ray 1.57A ) 5TX4 (X-ray 1.88A ) 5TY4 (EM 2.90A ) 7DV6 (X-ray 2.39A ) |
| DBSNP | rs17025864 rs780542125 rs56105708 rs761231369 rs28934568 rs34833812 rs104893812 rs104893813 rs104893814 rs35719192 rs1553630274 rs35766612 rs1050833 rs886039551 rs104893807 rs104893811 rs104893816 rs863223853 rs193922664 rs1575166666 rs121918714 rs104893810 rs104893815 rs104893809 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:1310899, ECO:0000269|PubMed:25893292}; Single-pass type I membrane protein {ECO:0000269|PubMed:1310899}. Membrane raft {ECO:0000269|PubMed:25893292}.; [Isoform 3]: Secreted {ECO:0000269|PubMed:34568316}. |
| Mouse PG classification | NA |
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