| Gene Information | |
|---|---|
| Gene Name | IRAK4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 460 |
| Protein Names | Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-64) |
| Target Name | interleukin-1 receptor-associated kinase 4 |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000198001 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9NWZ3 |
| Gene Card | IRAK4 |
| Uniprot ID | Q9NWZ3 |
| Pfam | PF07714 |
| In ASD | no |
| Allosteric Prediction | yes (0.438639408) |
| Ortholog in Animals | Alpaca_ IRAK4 ( ortholog_one2one ) Dog_ IRAK4 ( ortholog_one2one ) GuineaPig_ IRAK4 ( ortholog_one2one ) Macaque_ IRAK4 ( ortholog_one2one ) Mouse_ Irak4 ( ortholog_one2one ) Pig_ IRAK4 ( ortholog_one2one ) Rat_ Irak4 ( ortholog_one2one ) Rabbit_ IRAK4 ( ortholog_one2one ) |
| Ohnologs | IRAK1, IRAK3, IRAK2 |
| Paralogs | HASPIN, IRAK1, IRAK3, IRAK2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2NRU (X-ray 2.00A ) 2NRY (X-ray 2.15A ) 2O8Y (X-ray 2.40A ) 2OIB (X-ray 2.00A ) 2OIC (X-ray 2.40A ) 2OID (X-ray 2.30A ) 3MOP (X-ray 3.40A ) 4RMZ (X-ray 2.20A ) 4U97 (X-ray 2.65A ) 4U9A (X-ray 2.80A ) 4XS2 (X-ray 2.73A ) 4Y73 (X-ray 2.14A ) 4YO6 (X-ray 2.32A ) 4YP8 (X-ray 2.64A ) 4ZTL (X-ray 2.39A ) 4ZTM (X-ray 2.66A ) 4ZTN (X-ray 2.23A ) 5K72 (X-ray 2.22A ) 5K75 (X-ray 2.03A ) 5K76 (X-ray 2.74A ) 5K7G (X-ray 2.23A ) 5K7I (X-ray 2.31A ) 5KX7 (X-ray 2.80A ) 5KX8 (X-ray 2.67A ) 5T1S (X-ray 2.30A ) 5T1T (X-ray 2.34A ) 5UIQ (X-ray 2.64A ) 5UIR (X-ray 2.64A ) 5UIS (X-ray 2.50A ) 5UIT (X-ray 1.84A ) 5UIU (X-ray 2.02A ) 5W84 (X-ray 2.90A ) 5W85 (X-ray 2.25A ) 6EG9 (X-ray 2.41A ) 6EGA (X-ray 2.51A ) 6EGD (X-ray 2.10A ) 6EGE (X-ray 1.40A ) 6EGF (X-ray 2.61A ) 6F3D (X-ray 2.38A ) 6F3E (X-ray 2.67A ) 6F3G (X-ray 2.37A ) 6F3I (X-ray 2.14A ) 6LXY (X-ray 2.19A ) 6MOM (X-ray 2.10A ) 6N8G (X-ray 2.00A ) 6O8U (X-ray 1.80A ) 6O94 (X-ray 1.98A ) 6O95 (X-ray 1.77A ) 6O9D (X-ray 2.51A ) 6RFI (X-ray 2.31A ) 6RFJ (X-ray 2.61A ) 6THW (X-ray 2.44A ) 6THX (X-ray 1.99A ) 6THZ (X-ray 2.38A ) 6TI8 (X-ray 2.32A ) 6TIA (X-ray 2.52A ) 6UYA (X-ray 1.74A ) 6VQL (X-ray 2.07A ) 7C2V (X-ray 2.44A ) 7C2W (X-ray 3.20A ) 7QG1 (X-ray 2.07A ) 7QG2 (X-ray 3.03A ) 7QG3 (X-ray 2.11A ) 7QG5 (X-ray 2.30A ) 8DKS (X-ray 2.45A ) |
| DBSNP | rs56312115 rs377584435 rs143625818 rs138116867 rs113588409 rs4251469 rs568782766 rs142376871 rs4251583 rs55944915 rs4251545 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:21325272}. |
| Mouse PG classification | LPG |
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