| Gene Information | |
|---|---|
| Gene Name | IFITM3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 133 |
| Protein Names | Interferon-induced transmembrane protein 3 (Dispanin subfamily A member 2b) (DSPA2b) (Interferon-inducible protein 1-8U) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000142089 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q01628 |
| Gene Card | IFITM3 |
| Uniprot ID | Q01628 |
| Pfam | PF04505 |
| In ASD | no |
| Allosteric Prediction | no (-1.212061218) |
| Ortholog in Animals | Mouse_ Ifitm3 ( ortholog_many2many ) Mouse_ Ifitm2 ( ortholog_many2many ) Mouse_ Ifitm1 ( ortholog_many2many ) Mouse_ Ifitm7 ( ortholog_many2many ) Rat_ AABR07015596.1 ( ortholog_many2many ) Rat_ Ifitm1 ( ortholog_many2many ) Rat_ Ifitm3 ( ortholog_many2many ) Rat_ AABR07021463.1 ( ortholog_many2many ) Rat_ Ifitm2 ( ortholog_many2many ) |
| Ohnologs | NA |
| Paralogs | IFITM2, IFITM1, IFITM5, IFITM10 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1136853 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:20943977, ECO:0000269|PubMed:22511783, ECO:0000269|PubMed:26354436}; Single-pass type II membrane protein {ECO:0000269|PubMed:20943977, ECO:0000269|PubMed:22511783}. Late endosome membrane {ECO:0000269|PubMed:22046135}; Single-pass type II membrane protein {ECO:0000305}. Early endosome membrane {ECO:0000269|PubMed:26354436, ECO:0000269|PubMed:33270927}; Single-pass type II membrane protein. Lysosome membrane {ECO:0000269|PubMed:22046135, ECO:0000269|PubMed:26354436, ECO:0000269|PubMed:33270927}; Single-pass type II membrane protein {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:30983867}. Note=Co-localizes with BRI3 isoform 1 at the perinuclear region. {ECO:0000269|PubMed:30983867}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |