| Gene Information | |
|---|---|
| Gene Name | CHRM1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 460 |
| Protein Names | Muscarinic acetylcholine receptor M1 |
| Target Name | muscarinic acetylcholine receptor m1 |
| Target Type | Successful target |
| Gene Age | 382 ( ENSG00000168539 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P11229 |
| Gene Card | CHRM1 |
| Uniprot ID | P11229 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.634262954) |
| Ortholog in Animals | Alpaca_ CHRM1 ( ortholog_one2one ) Dog_ CHRM1 ( ortholog_one2one ) GuineaPig_ CHRM1 ( ortholog_one2one ) Macaque_ CHRM1 ( ortholog_one2one ) Mouse_ Chrm1 ( ortholog_one2one ) Rat_ Chrm1 ( ortholog_one2one ) |
| Ohnologs | CHRM5, CHRM3, CHRM2 |
| Paralogs | HRH2, TAAR6, DRD4, HRH1, DRD1, GPR52, HTR1A, HTR1D, CHRM3, CHRM4, HRH3, TAAR5, HTR4, TAAR1, GPR21, HRH4, TAAR9, CHRM5, TAAR8, DRD3, GPR84, CHRM2, GPR161, DRD5, TAAR2 |
| Tissue | brain, prostate, salivary.gland, cerebral.cortex, caudate.nucleus, nucleus.accumbens, putamen |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5CXV (X-ray 2.70A ) 6OIJ (EM 3.30A ) 6WJC (X-ray 2.55A ) 6ZFZ (X-ray 2.17A ) 6ZG4 (X-ray 2.33A ) 6ZG9 (X-ray 2.50A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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