Gene Information
Gene NameVRK1
OrganismHomo sapiens (Human)
Gene Length396
Protein NamesSerine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1)
Target NameNA
Target TypeNA
Gene Age>4290 ( ENSG00000100749 )
Evolutionary StageEumetazoa
AlphaFoldDBQ99986
Gene CardVRK1
Uniprot IDQ99986
PfamPF00069
In ASDno
Allosteric Predictionyes (0.362750672)
Ortholog in AnimalsAlpaca_ VRK1 ( ortholog_one2one )
Dog_ VRK1 ( ortholog_one2one )
GuineaPig_ VRK1 ( ortholog_one2one )
Macaque_ VRK1 ( ortholog_one2one )
Mouse_ Vrk1 ( ortholog_one2one )
Pig_ VRK1 ( ortholog_one2one )
Rat_ Vrk1 ( ortholog_one2one )
Rabbit_ VRK1 ( ortholog_one2one )
OhnologsVRK2
ParalogsCSNK1G3, TTBK2, VRK3, CSNK1A1L, CSNK1G1, CSNK1A1, CDC7, CSNK1G2, CSNK1E, CSNK1D, VRK2, TTBK1
TissueNA
Tissue SpecificityWidely expressed. Highly expressed in fetal liver, testis and thymus. {ECO:0000269|PubMed:9344656}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2KTY  (NMR  -  )  2KUL  (NMR  -  )  2LAV  (NMR  -  )  2RSV  (NMR  -  )  3OP5  (X-ray  2.40A  )  5UKF  (X-ray  2.40A  )  5UVF  (X-ray  2.00A  )  6AC9  (X-ray  2.07A  )  6BP0  (X-ray  1.90A  )  6BRU  (X-ray  1.80A  )  6BTW  (X-ray  1.90A  )  6BU6  (X-ray  1.80A  )  6CFM  (X-ray  2.45A  )  6CMM  (X-ray  2.10A  )  6CNX  (X-ray  2.00A  )  6CQH  (X-ray  2.15A  )  6CSW  (X-ray  2.25A  )  6DD4  (X-ray  2.10A  )  6NPN  (X-ray  2.20A  )  6VXU  (X-ray  2.00A  )  6VZH  (X-ray  2.55A  )  7M10  (X-ray  1.15A  )  7TAN  (EM  3.00A  ) 
DBSNP NA 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:10951572, ECO:0000269|PubMed:14645249, ECO:0000269|PubMed:15105425, ECO:0000269|PubMed:16704422, ECO:0000269|PubMed:18617507}. Cytoplasm {ECO:0000269|PubMed:18617507}. Note=Dispersed throughout the cell but not located on mitotic spindle or chromatids during mitosis.
Mouse PG classificationLPG
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