| Gene Information | |
|---|---|
| Gene Name | CAPNS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 268 |
| Protein Names | Calpain small subunit 1 (CSS1) (Calcium-activated neutral proteinase small subunit) (CANP small subunit) (Calcium-dependent protease small subunit) (CDPS) (Calcium-dependent protease small subunit 1) (Calpain regulatory subunit) |
| Target Name | calpain small subunit 1 |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000126247 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P04632 |
| Gene Card | CAPNS1 |
| Uniprot ID | P04632 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | yes (0.399522181) |
| Ortholog in Animals | Alpaca_ CAPNS1 ( ortholog_one2one ) Dog_ CAPNS1 ( ortholog_one2one ) GuineaPig_ CAPNS1 ( ortholog_one2one ) Macaque_ CAPNS1 ( ortholog_one2one ) Mouse_ Capns1 ( ortholog_one2one ) Pig_ CAPNS1 ( ortholog_one2one ) Rat_ Capns1 ( ortholog_one2one ) Rabbit_ CAPNS1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CAPN1, PEF1, GCA, SRI, CAPN9, PDCD6, CAPN2, CAPN5, CAPN14, CAPN15, CAPN7, ADGB, CAPN6, CAPN8, CAPN3, CAPN12, CAPNS2, CAPN11, CAPN13, CAPN10 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002990(Rat);0.05(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1KFU (X-ray 2.50A ) 1KFX (X-ray 3.15A ) 4PHJ (X-ray 1.60A ) 4PHK (X-ray 2.05A ) 4PHM (X-ray 2.03A ) 4WQ2 (X-ray 1.64A ) 4WQ3 (X-ray 1.79A ) 5D69 (X-ray 1.97A ) 6QLB (X-ray 2.32A ) |
| DBSNP | rs17878750 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Translocates to the plasma membrane upon calcium binding. {ECO:0000250}. |
| Mouse PG classification | NA |
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