| Gene Information | |
|---|---|
| Gene Name | GJA8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 433 |
| Protein Names | Gap junction alpha-8 protein (Connexin-50) (Cx50) (Lens fiber protein MP70) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000121634 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P48165 |
| Gene Card | GJA8 |
| Uniprot ID | P48165 |
| Pfam | PF00029; PF03509 |
| In ASD | no |
| Allosteric Prediction | no (-0.933303735) |
| Ortholog in Animals | Alpaca_ GJA8 ( ortholog_one2one ) Dog_ GJA8 ( ortholog_one2one ) GuineaPig_ GJA8 ( ortholog_one2one ) Macaque_ GJA8 ( ortholog_one2one ) Mouse_ Gja8 ( ortholog_one2one ) Pig_ GJA8 ( ortholog_one2one ) Rat_ Gja8 ( ortholog_one2one ) Rabbit_ GJA8 ( ortholog_one2one ) |
| Ohnologs | GJA10, GJA1, GJA1P1, GJD3, GJC2 |
| Paralogs | GJB3, GJB1, GJB2, GJB5, GJB4, GJB6, GJB7, GJA10, GJA9, GJD2, GJD3, GJC3, GJC2, GJC1, GJD4, GJE1, GJA4, GJA1, GJA5, GJA3 |
| Tissue | NA |
| Tissue Specificity | Eye lens. {ECO:0000269|PubMed:19756179}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs80358203 rs1114167309 rs80358204 rs864309688 rs1553242554 rs121434643 rs80358201 rs80358200 rs782306193 rs1114167310 rs80358205 rs80358202 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:16397066, ECO:0000269|PubMed:18006672, ECO:0000269|PubMed:19756179, ECO:0000269|PubMed:26004348}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P55917}. Cell junction, gap junction {ECO:0000269|PubMed:18006672, ECO:0000269|PubMed:19756179}. |
| Mouse PG classification | HPG |
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