| Gene Information | |
|---|---|
| Gene Name | NIPBL |
| Organism | Homo sapiens (Human) |
| Gene Length | 2804 |
| Protein Names | Nipped-B-like protein (Delangin) (SCC2 homolog) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000164190 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | NA |
| Gene Card | NIPBL |
| Uniprot ID | Q6KC79 |
| Pfam | PF12765; PF12830 |
| In ASD | no |
| Allosteric Prediction | no (-0.653927782) |
| Ortholog in Animals | Alpaca_ NIPBL ( ortholog_one2one ) Dog_ NIPBL ( ortholog_one2one ) GuineaPig_ NIPBL ( ortholog_one2one ) Macaque_ NIPBL ( ortholog_one2one ) Mouse_ Nipbl ( ortholog_one2one ) Pig_ NIPBL ( ortholog_one2one ) Rat_ Nipbl ( ortholog_one2one ) Rabbit_ NIPBL ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Highly expressed in heart, skeletal muscle, fetal and adult liver, fetal and adult kidney. Expressed at intermediates level in thymus, placenta, peripheral leukocyte and small intestine. Weakly or not expressed in brain, colon, spleen and lung. {ECO:0000269|PubMed:15146185, ECO:0000269|PubMed:15146186}. |
| Pharmacological Animal Models | 0.048586(Chimpanzee);0.036614(Mouse);NULL(Rat);0.137843(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 6WG3 (EM 5.30A ) 6WGE (EM 3.90A ) |
| DBSNP | rs1390490298 rs142923613 rs587784042 rs16903425 rs2291703 rs3822471 rs149629686 rs587783929 rs121918266 rs121918268 rs727503769 rs587784000 rs80358376 rs587784024 rs587784025 rs587784036 rs121918265 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. Chromosome {ECO:0000250|UniProtKB:Q6KCD5}. |
| Mouse PG classification | NA |
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