| Gene Information | |
|---|---|
| Gene Name | PA2G4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 394 |
| Protein Names | Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4 homolog) (hG4-1) (ErbB3-binding protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000170515 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UQ80 |
| Gene Card | PA2G4 |
| Uniprot ID | Q9UQ80 |
| Pfam | PF00557 |
| In ASD | no |
| Allosteric Prediction | yes (0.361017571) |
| Ortholog in Animals | Alpaca_ PA2G4 ( ortholog_one2one ) Dog_ PA2G4 ( ortholog_one2one ) GuineaPig_ PA2G4 ( ortholog_one2one ) Mouse_ Pa2g4 ( ortholog_one2one ) Rat_ AABR07065265.1 ( ortholog_one2one ) Rabbit_ PA2G4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | XPNPEP1, METAP1D, XPNPEP2, METAP2, METAP1, XPNPEP3, PEPD |
| Tissue | NA |
| Tissue Specificity | Isoform 2 is undetectable whereas isoform 1 is strongly expressed in cancer cells (at protein level). Isoform 1 and isoform 2 are widely expressed, including heart, brain, lung, pancreas, skeletal muscle, kidney, placenta and liver. {ECO:0000269|PubMed:10682683, ECO:0000269|PubMed:15064750, ECO:0000269|PubMed:19037095}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.011264(Rat);0.130034(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2Q8K (X-ray 1.60A ) 3J2I (EM 11.90A ) 6CHT (X-ray 3.17A ) 6LSR (EM 3.13A ) 6SXO (EM 3.30A ) 6WM8 (X-ray 2.60A ) 6Z6L (EM 3.00A ) 6Z6M (EM 3.10A ) 6Z6N (EM 2.90A ) 6ZM7 (EM 2.70A ) 6ZME (EM 3.00A ) 6ZMI (EM 2.60A ) 6ZMO (EM 3.10A ) 7BHP (EM 3.30A ) |
| DBSNP | NA |
| Subcellular location [CC] | [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:16832058, ECO:0000269|PubMed:19037095}. Nucleus, nucleolus {ECO:0000269|PubMed:16832058, ECO:0000269|PubMed:19037095}. Note=Translocates to the nucleus upon treatment with HRG. Phosphorylation at Ser-361 by PKC/PRKCD regulates its nucleolar localization. {ECO:0000269|PubMed:16832058}.; [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:16832058, ECO:0000269|PubMed:19037095}. |
| Mouse PG classification | NA |
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