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Gene Information
Gene Name
EPHX2
Organism
Homo sapiens (Human)
Gene Length
555
Protein Names
Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2 (CEH) (EC 3.3.2.10) (Epoxide hydratase) (Soluble epoxide hydrolase) (SEH); Lipid-phosphate phosphatase (EC 3.1.3.76)]
Target Name
soluble epoxide hydrolase
Target Type
Clinical trial target
Gene Age
680 ( ENSG00000120915 )
Evolutionary Stage
Euk+Bac
AlphaFoldDB
P34913
Gene Card
EPHX2
Uniprot ID
P34913
Pfam
PF00561; PF13419
In ASD
yes
Allosteric Prediction
yes (1.000248364)
Ortholog in Animals
Alpaca_ EPHX2 ( ortholog_one2one )
Dog_ EPHX2 ( ortholog_one2one )
GuineaPig_ EPHX2 ( ortholog_one2one )
Macaque_ EPHX2 ( ortholog_one2one )
Mouse_ Ephx2 ( ortholog_one2one )
Pig_ EPHX2 ( ortholog_one2one )
Rat_ Ephx2 ( ortholog_one2one )
Ohnologs
NA
Paralogs
SERHL2, MEST, EPHX4, ABHD6, ABHD8, ABHD11, ABHD5, ABHD4, ABHD14B, BPHL, ABHD14A, EPHX3
Tissue
NA
Tissue Specificity
NA
Pharmacological Animal Models
NA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
1S8O
(X-ray
2.60A
)
1VJ5
(X-ray
2.35A
)
1ZD2
(X-ray
3.00A
)
1ZD3
(X-ray
2.30A
)
1ZD4
(X-ray
2.70A
)
1ZD5
(X-ray
2.60A
)
3ANS
(X-ray
1.98A
)
3ANT
(X-ray
2.40A
)
3I1Y
(X-ray
2.47A
)
3I28
(X-ray
1.95A
)
3KOO
(X-ray
2.79A
)
3OTQ
(X-ray
3.00A
)
3PDC
(X-ray
2.60A
)
3WK4
(X-ray
2.11A
)
3WK5
(X-ray
2.77A
)
3WK6
(X-ray
2.10A
)
3WK7
(X-ray
2.20A
)
3WK8
(X-ray
2.20A
)
3WK9
(X-ray
2.20A
)
3WKA
(X-ray
2.01A
)
3WKB
(X-ray
2.20A
)
3WKC
(X-ray
2.20A
)
3WKD
(X-ray
2.48A
)
3WKE
(X-ray
2.75A
)
4C4X
(X-ray
2.17A
)
4C4Y
(X-ray
2.41A
)
4C4Z
(X-ray
2.06A
)
4HAI
(X-ray
2.55A
)
4J03
(X-ray
2.92A
)
4JNC
(X-ray
1.96A
)
4OCZ
(X-ray
2.94A
)
4OD0
(X-ray
2.92A
)
4X6X
(X-ray
1.80A
)
4X6Y
(X-ray
2.10A
)
4Y2J
(X-ray
2.15A
)
4Y2P
(X-ray
2.05A
)
4Y2Q
(X-ray
2.40A
)
4Y2R
(X-ray
2.45A
)
4Y2S
(X-ray
2.30A
)
4Y2T
(X-ray
2.40A
)
4Y2U
(X-ray
2.75A
)
4Y2V
(X-ray
2.40A
)
4Y2X
(X-ray
2.50A
)
4Y2Y
(X-ray
2.30A
)
5AHX
(X-ray
2.00A
)
5AI0
(X-ray
1.75A
)
5AI4
(X-ray
1.93A
)
5AI5
(X-ray
2.28A
)
5AI6
(X-ray
2.30A
)
5AI8
(X-ray
1.85A
)
5AI9
(X-ray
1.80A
)
5AIA
(X-ray
2.26A
)
5AIB
(X-ray
1.95A
)
5AIC
(X-ray
1.89A
)
5AK3
(X-ray
2.28A
)
5AK4
(X-ray
1.79A
)
5AK5
(X-ray
2.22A
)
5AK6
(X-ray
2.15A
)
5AKE
(X-ray
2.26A
)
5AKG
(X-ray
2.51A
)
5AKH
(X-ray
2.10A
)
5AKI
(X-ray
1.81A
)
5AKJ
(X-ray
2.03A
)
5AKK
(X-ray
1.90A
)
5AKL
(X-ray
2.00A
)
5AKX
(X-ray
2.09A
)
5AKY
(X-ray
2.18A
)
5AKZ
(X-ray
2.18A
)
5ALD
(X-ray
2.26A
)
5ALE
(X-ray
1.95A
)
5ALF
(X-ray
2.32A
)
5ALG
(X-ray
2.40A
)
5ALH
(X-ray
1.90A
)
5ALI
(X-ray
1.85A
)
5ALJ
(X-ray
2.10A
)
5ALK
(X-ray
2.33A
)
5ALL
(X-ray
2.20A
)
5ALM
(X-ray
2.00A
)
5ALN
(X-ray
2.00A
)
5ALO
(X-ray
2.00A
)
5ALP
(X-ray
2.06A
)
5ALQ
(X-ray
2.78A
)
5ALR
(X-ray
2.60A
)
5ALS
(X-ray
2.57A
)
5ALT
(X-ray
2.15A
)
5ALU
(X-ray
1.87A
)
5ALV
(X-ray
1.80A
)
5ALW
(X-ray
2.20A
)
5ALX
(X-ray
2.23A
)
5ALY
(X-ray
1.90A
)
5ALZ
(X-ray
2.30A
)
5AM0
(X-ray
1.88A
)
5AM1
(X-ray
2.15A
)
5AM2
(X-ray
1.70A
)
5AM3
(X-ray
2.20A
)
5AM4
(X-ray
1.87A
)
5AM5
(X-ray
2.26A
)
5FP0
(X-ray
2.35A
)
5MWA
(X-ray
1.55A
)
6AUM
(X-ray
2.95A
)
6I5E
(X-ray
2.60A
)
6I5G
(X-ray
2.00A
)
7EBA
(X-ray
2.30A
)
DBSNP
rs72473930
rs72475803
rs41507953
rs17057255
rs57699806
rs72475821
rs751141
rs72475894
rs68053459
Subcellular location [CC]
Cytoplasm. Peroxisome.
Mouse PG classification
NA
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