Gene Information
Gene NamePPP3CA
OrganismHomo sapiens (Human)
Gene Length521
Protein NamesProtein phosphatase 3 catalytic subunit alpha (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin A alpha) (Calmodulin-dependent calcineurin A subunit alpha isoform) (CNA alpha) (Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform)
Target Nameserine/threonine-protein phosphatase 2b catalytic subunit alpha isoform
Target TypeNA
Gene Age645 ( ENSG00000138814 )
Evolutionary StageEukaryota
AlphaFoldDBQ08209
Gene CardPPP3CA
Uniprot IDQ08209
PfamPF00149
In ASDno
Allosteric Predictionyes (1.117904134)
Ortholog in AnimalsAlpaca_ PPP3CA ( ortholog_one2one )
Dog_ PPP3CA ( ortholog_one2one )
GuineaPig_ PPP3CA ( ortholog_one2one )
Macaque_ PPP3CA ( ortholog_one2one )
Mouse_ Ppp3ca ( ortholog_one2one )
Pig_ PPP3CA ( ortholog_one2one )
Rat_ Ppp3ca ( ortholog_one2one )
Rabbit_ PPP3CA ( ortholog_one2one )
OhnologsPPP3CB
ParalogsPPP3CC, PPP3CB, PPP6C, PPP5C, PPP2CB, PPP2CA, PPEF2, PPP4C, PPEF1, PPP1CA, PPP1CC, PPP1CB
TissueNA
Tissue SpecificityExpressed in keratinocytes (at protein level) (PubMed:29043977). Expressed in lymphoblasts (at protein level) (PubMed:30254215). {ECO:0000269|PubMed:29043977, ECO:0000269|PubMed:30254215}.
Pharmacological Animal ModelsNULL(Chimpanzee);0.209548(Mouse);NULL(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1AUI  (X-ray  2.10A  )  1M63  (X-ray  2.80A  )  1MF8  (X-ray  3.10A  )  2JOG  (NMR  -  )  2JZI  (NMR  -  )  2P6B  (X-ray  2.30A  )  2R28  (X-ray  1.86A  )  2W73  (X-ray  1.45A  )  3LL8  (X-ray  2.00A  )  4F0Z  (X-ray  1.70A  )  4Q5U  (X-ray  1.95A  )  5C1V  (X-ray  3.35A  )  5SVE  (X-ray  2.60A  )  6NUC  (X-ray  1.90A  )  6NUF  (X-ray  1.90A  )  6NUU  (X-ray  2.30A  )  6UUQ  (X-ray  1.85A  ) 
DBSNP rs1553925558  rs199706529  rs1553923787  rs1553920374  rs1560567347  rs1560567337 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:19154138, ECO:0000269|PubMed:22343722}. Cell membrane {ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:28881575};
Peripheral membrane protein {ECO:0000269|PubMed:22343722}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P63329}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:P63329}. Cell projection, dendritic spine {ECO:0000269|PubMed:22343722}. Note=Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle (By similarity). Recruited to the cell membrane by scaffold protein AKAP5 following L-type Ca(2+)-channel activation (PubMed:22343722). {ECO:0000250|UniProtKB:P63329, ECO:0000269|PubMed:22343722}.
Mouse PG classificationNA
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