| Gene Information | |
|---|---|
| Gene Name | PPP2CA |
| Organism | Homo sapiens (Human) |
| Gene Length | 309 |
| Protein Names | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C) |
| Target Name | serine/threonine pp2a-alpha |
| Target Type | Clinical trial target |
| Gene Age | >4290 ( ENSG00000113575 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P67775 |
| Gene Card | PPP2CA |
| Uniprot ID | P67775 |
| Pfam | PF00149 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000295217) |
| Ortholog in Animals | Alpaca_ PPP2CA ( ortholog_one2one ) Dog_ PPP2CA ( ortholog_one2one ) GuineaPig_ PPP2CA ( ortholog_one2one ) Mouse_ Ppp2ca ( ortholog_one2one ) Pig_ PPP2CA ( ortholog_one2one ) Rat_ Ppp2ca ( ortholog_one2many ) |
| Ohnologs | PPP2CB |
| Paralogs | PPP3CC, PPP3CB, PPP6C, PPP5C, PPEF2, PPP4C, PPP3CA, PPEF1, PPP1CA, PPP1CC, PPP1CB, PPP2CB |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.401065(Rat);0.153235(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2IAE (X-ray 3.50A ) 2IE3 (X-ray 2.80A ) 2IE4 (X-ray 2.60A ) 2NPP (X-ray 3.30A ) 2NYL (X-ray 3.80A ) 2NYM (X-ray 3.60A ) 3C5W (X-ray 2.80A ) 3DW8 (X-ray 2.85A ) 3FGA (X-ray 2.70A ) 3K7V (X-ray 2.85A ) 3K7W (X-ray 2.96A ) 3P71 (X-ray 2.70A ) 4I5L (X-ray 2.43A ) 4I5N (X-ray 2.80A ) 4IYP (X-ray 2.80A ) 4LAC (X-ray 2.82A ) 4NY3 (X-ray 1.80A ) 5W0W (X-ray 3.80A ) 6NTS (EM 3.63A ) 7CUN (EM 3.50A ) 7K36 (EM 3.30A ) 7PKS (EM 3.60A ) 7SOY (EM 3.40A ) |
| DBSNP | rs11552681 rs1580641099 rs1561737008 rs764595667 rs1580637688 rs1580637673 rs915349596 rs148071386 rs1580636668 rs1580636665 rs1561733474 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:16541025}. Nucleus {ECO:0000269|PubMed:16541025}. Chromosome, centromere {ECO:0000269|PubMed:16541025}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:16541025}. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres (PubMed:16541025). During mitosis, also found at spindle poles (PubMed:16541025). Centromeric localization requires the presence of SGO2 (By similarity). {ECO:0000250|UniProtKB:P63330, ECO:0000269|PubMed:16541025}. |
| Mouse PG classification | NA |
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