| Gene Information | |
|---|---|
| Gene Name | CDC42BPA |
| Organism | Homo sapiens (Human) |
| Gene Length | 1732 |
| Protein Names | Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000143776 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q5VT25 |
| Gene Card | CDC42BPA |
| Uniprot ID | Q5VT25 |
| Pfam | PF00130; PF00780; PF08826; PF15796; PF00069; PF00433 |
| In ASD | no |
| Allosteric Prediction | no (-0.574805583) |
| Ortholog in Animals | Alpaca_ CDC42BPA ( ortholog_one2one ) Dog_ CDC42BPA ( ortholog_one2one ) GuineaPig_ CDC42BPA ( ortholog_one2one ) Macaque_ CDC42BPA ( ortholog_one2one ) Mouse_ Cdc42bpa ( ortholog_one2one ) Pig_ CDC42BPA ( ortholog_one2one ) Rat_ Cdc42bpa ( ortholog_one2one ) Rabbit_ CDC42BPA ( ortholog_one2one ) |
| Ohnologs | CDC42BPG, CDC42BPB |
| Paralogs | CDC42BPG, CDC42BPB, CIT, ROCK1, ROCK2 |
| Tissue | NA |
| Tissue Specificity | Abundant in the heart, brain, skeletal muscle, kidney, and pancreas, with little or no expression in the lung and liver. {ECO:0000269|PubMed:9092543}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs34614709 rs56364976 rs56119119 rs34943764 rs56219089 rs961490 rs1929860 rs55687355 rs2297417 rs2802269 rs2802269 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:O54874}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q3UU96}. Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent. Localizes in the lamellipodium in a FAM89B/LRAP25-dependent manner. {ECO:0000250|UniProtKB:O54874, ECO:0000250|UniProtKB:Q3UU96}. |
| Mouse PG classification | NA |
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