| Gene Information | |
|---|---|
| Gene Name | IL15 |
| Organism | Homo sapiens (Human) |
| Gene Length | 162 |
| Protein Names | Interleukin-15 (IL-15) |
| Target Name | interleukin-15 |
| Target Type | Clinical trial target |
| Gene Age | 332 ( ENSG00000164136 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P40933 |
| Gene Card | IL15 |
| Uniprot ID | P40933 |
| Pfam | PF02372 |
| In ASD | yes |
| Allosteric Prediction | yes (0.513010074) |
| Ortholog in Animals | Alpaca_ IL15 ( ortholog_one2one ) Dog_ IL15 ( ortholog_one2one ) GuineaPig_ IL15 ( ortholog_one2one ) Macaque_ IL15 ( ortholog_one2one ) Mouse_ Il15 ( ortholog_one2one ) Pig_ IL15 ( ortholog_one2one ) Rat_ Il15 ( ortholog_one2one ) Rabbit_ IL15 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver and kidney. IL15-S21AA is preferentially expressed in tissues such as testis and thymus. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002990(Rat);0.15(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2XQB (X-ray 2.60A ) 2Z3Q (X-ray 1.85A ) 2Z3R (X-ray 2.00A ) 4GS7 (X-ray 2.35A ) |
| DBSNP | NA |
| Subcellular location [CC] | [Isoform IL15-S48AA]: Secreted.; [Isoform IL15-S21AA]: Cytoplasm. Nucleus. Note=IL15-S21AA is not secreted, but rather is stored intracellularly, appearing in the nucleus and cytoplasmic components. |
| Mouse PG classification | NA |
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