Gene Information
Gene NameNFE2L1
OrganismHomo sapiens (Human)
Gene Length772
Protein NamesEndoplasmic reticulum membrane sensor NFE2L1 (Locus control region-factor 1) (LCR-F1) (Nuclear factor erythroid 2-related factor 1) (NF-E2-related factor 1) (NFE2-related factor 1) (Nuclear factor, erythroid derived 2, like 1) (Protein NRF1, p120 form) (Transcription factor 11) (TCF-11) [Cleaved into: Transcription factor NRF1 (Protein NRF1, p110 form)]
Target Namenuclear factor erythroid 2-related factor 1
Target TypeNA
Gene Age680 ( ENSG00000082641 )
Evolutionary StageEumetazoa
AlphaFoldDBQ14494
Gene CardNFE2L1
Uniprot IDQ14494
PfamPF03131
In ASDno
Allosteric Predictionno (-0.653697733)
Ortholog in AnimalsAlpaca_ NFE2L1 ( ortholog_one2one )
Dog_ NFE2L1 ( ortholog_one2one )
GuineaPig_ NFE2L1 ( ortholog_one2one )
Macaque_ NFE2L1 ( ortholog_one2one )
Mouse_ Nfe2l1 ( ortholog_one2one )
Pig_ NFE2L1 ( ortholog_one2one )
Rat_ Nfe2l1 ( ortholog_one2one )
Rabbit_ NFE2L1 ( ortholog_one2one )
OhnologsNFE2L3, NFE2L2
ParalogsNFE2L3, NFE2, NFE2L2
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs2229367 
Subcellular location [CC][Endoplasmic reticulum membrane sensor NFE2L1]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16687406, ECO:0000269|PubMed:24448410, ECO:0000269|PubMed:24998528};
Single-pass type II membrane protein {ECO:0000269|PubMed:20932482, ECO:0000269|PubMed:24448410}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:16687406, ECO:0000269|PubMed:24448410, ECO:0000269|PubMed:24998528};
Single-pass type III membrane protein {ECO:0000269|PubMed:20932482, ECO:0000269|PubMed:24448410}. Note=In normal conditions, probably has a single-pass type II membrane protein topology, with the DNA-binding domain facing the endoplasmic reticulum lumen (PubMed:24448410). Following cellular stress, it is rapidly and efficiently retrotranslocated to the cytosolic side of the membrane, a process dependent on p97/VCP, to have a single-pass type III membrane protein topology with the major part of the protein facing the cytosol (PubMed:24448410). Retrotranslocated proteins are normally rapidly degraded by the proteasome and active species do not accumulate (PubMed:24448410). However, retrotranslocated protein NFE2L1 escapes degradation and is cleaved at Leu-104 by DDI2, releasing the protein from the endoplasmic reticulum membrane and forming the transcription factor NRF1 that translocates into the nucleus (PubMed:24448410). {ECO:0000269|PubMed:24448410}.;
[Transcription factor NRF1]: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:16687406, ECO:0000269|PubMed:20932482, ECO:0000269|PubMed:24998528, ECO:0000269|PubMed:27528193}. Note=Translocates into the nucleus following cleavage of Endoplasmic reticulum membrane sensor NFE2L1 by aspartyl protease DDI2. {ECO:0000269|PubMed:24448410, ECO:0000269|PubMed:27528193}.
Mouse PG classificationNA
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