| Gene Information | |
|---|---|
| Gene Name | DAG1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 895 |
| Protein Names | Dystroglycan 1 (Dystroglycan) (Dystrophin-associated glycoprotein 1) [Cleaved into: Alpha-dystroglycan (Alpha-DG); Beta-dystroglycan (Beta-DG)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000173402 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q14118 |
| Gene Card | DAG1 |
| Uniprot ID | Q14118 |
| Pfam | PF18424; PF05454 |
| In ASD | no |
| Allosteric Prediction | yes (0.124468297) |
| Ortholog in Animals | Alpaca_ DAG1 ( ortholog_one2one ) Dog_ DAG1 ( ortholog_one2one ) GuineaPig_ DAG1 ( ortholog_one2one ) Macaque_ DAG1 ( ortholog_one2one ) Mouse_ Dag1 ( ortholog_one2one ) Pig_ DAG1 ( ortholog_one2one ) Rat_ Dag1 ( ortholog_one2one ) Rabbit_ DAG1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in a variety of fetal and adult tissues. In epidermal tissue, located to the basement membrane. Also expressed in keratinocytes and fibroblasts. {ECO:0000269|PubMed:15175026, ECO:0000269|PubMed:8268918}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1EG4 (X-ray 2.00A ) 2MK7 (NMR - ) 5GGP (X-ray 1.60A ) 5LLK (X-ray 1.80A ) 6JJY (X-ray 2.30A ) 7E9K (X-ray 2.05A ) 7E9L (X-ray 2.10A ) |
| DBSNP | rs2131107 rs189360006 rs117209107 rs193922955 rs797045023 |
| Subcellular location [CC] | [Alpha-dystroglycan]: Secreted, extracellular space.; [Beta-dystroglycan]: Cell membrane {ECO:0000269|PubMed:18764929}; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Nucleus, nucleoplasm {ECO:0000269|PubMed:18764929}. Cell membrane, sarcolemma {ECO:0000250}. Postsynaptic cell membrane {ECO:0000250}. Note=The monomeric form translocates to the nucleus via the action of importins and depends on RAN. Nuclear transport is inhibited by Tyr-892 phosphorylation. In skeletal muscle, this phosphorylated form locates to a vesicular internal membrane compartment. In muscle cells, sarcolemma localization requires the presence of ANK2, while localization to costameres requires the presence of ANK3. Localizes to neuromuscular junctions (NMJs) in the presence of ANK2 (By similarity). In peripheral nerves, localizes to the Schwann cell membrane. Colocalizes with ERM proteins in Schwann-cell microvilli. {ECO:0000250}. |
| Mouse PG classification | LPG |
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