| Gene Information | |
|---|---|
| Gene Name | DSG1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1049 |
| Protein Names | Desmoglein-1 (Cadherin family member 4) (Desmosomal glycoprotein 1) (DG1) (DGI) (Pemphigus foliaceus antigen) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000134760 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q02413 |
| Gene Card | DSG1 |
| Uniprot ID | Q02413 |
| Pfam | PF01049; PF00028 |
| In ASD | no |
| Allosteric Prediction | no (-0.194658377) |
| Ortholog in Animals | Alpaca_ DSG1 ( ortholog_one2one ) Dog_ DSG1 ( ortholog_one2one ) GuineaPig_ DSG1 ( ortholog_one2one ) Macaque_ DSG1 ( ortholog_one2one ) Mouse_ Dsg1b ( ortholog_one2many ) Mouse_ Dsg1c ( ortholog_one2many ) Mouse_ Dsg1a ( ortholog_one2many ) Pig_ DSG1 ( ortholog_one2one ) Rat_ Dsg1 ( ortholog_one2one ) Rabbit_ DSG1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DSG3, DSG4, DSG2, DSC2, DSC1, DSC3 |
| Tissue | skin, tongue, zone.of.skin, lower.leg.skin, suprapubic.skin |
| Tissue Specificity | Epidermis, tongue, tonsil and esophagus. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1426310 rs16961655 rs8091003 rs8091117 rs16961689 rs34302455 rs35360042 rs16961692 rs3752094 rs3752095 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:Q7TSF1}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q7TSF1}. Cell junction, desmosome {ECO:0000269|PubMed:34368962}. Cytoplasm {ECO:0000269|PubMed:34368962}. Nucleus {ECO:0000269|PubMed:34368962}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |