| Gene Information | |
|---|---|
| Gene Name | HLA-DRB3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 266 |
| Protein Names | HLA class II histocompatibility antigen, DR beta 3 chain (MHC class II antigen DRB3) |
| Target Name | hla-dr |
| Target Type | NA |
| Gene Age | 3 ( ENSG00000196101 ) 3 ( ENSG00000230463 ) 3 ( ENSG00000231679 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P79483 |
| Gene Card | HLA-DRB3 |
| Uniprot ID | P79483 |
| Pfam | PF07654; PF00969 |
| In ASD | no |
| Allosteric Prediction | yes (0.256301247) |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in professional APCs: monocyte/macrophages, dendritic cells and B cells (at protein level). {ECO:0000269|PubMed:19531622, ECO:0000269|PubMed:19830726}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2Q6W (X-ray 2.25A ) 3C5J (X-ray 1.80A ) 4H1L (X-ray 3.30A ) |
| DBSNP | rs1071747 rs1071748 rs1136752 rs200581589 rs147440497 rs202185589 rs142793258 rs1407020168 rs138849995 rs707956 rs200042906 rs200042906 rs1059580 rs774894415 rs79606458 rs144532965 rs144532965 rs41541218 rs696318 rs696318 rs17878857 rs1059598 rs115817940 rs1136778 rs41556512 rs75709987 rs139485758 rs142204283 rs147669022 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:18305173, ECO:0000269|PubMed:19531622, ECO:0000269|PubMed:19830726}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000255}. Autolysosome membrane {ECO:0000250|UniProtKB:P01911}; Single-pass type I membrane protein {ECO:0000255}. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation (PubMed:18305173). Component of immunological synapses at the interface between T cell and APC. {ECO:0000250|UniProtKB:P01911}. |
| Mouse PG classification | NA |
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