| Gene Information | |
|---|---|
| Gene Name | PLA2G5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 138 |
| Protein Names | Phospholipase A2 group V (EC 3.1.1.4) (PLA2-10) (Phosphatidylcholine 2-acylhydrolase 5) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000127472 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P39877 |
| Gene Card | PLA2G5 |
| Uniprot ID | P39877 |
| Pfam | PF00068 |
| In ASD | no |
| Allosteric Prediction | no (-0.735156423) |
| Ortholog in Animals | Alpaca_ PLA2G5 ( ortholog_one2one ) Dog_ PLA2G5 ( ortholog_one2one ) GuineaPig_ PLA2G5 ( ortholog_one2one ) Macaque_ PLA2G5 ( ortholog_one2one ) Mouse_ Pla2g5 ( ortholog_one2one ) Pig_ PLA2G5 ( ortholog_one2one ) Rat_ Pla2g5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PLA2G2D, PLA2G2C, PLA2G2F, PLA2G10, PLA2G2A, PLA2G2E, PLA2G1B, OC90 |
| Tissue | heart, ovary, placenta, testis |
| Tissue Specificity | Heart, placenta and less abundantly, in lung. Detected in the outer and inner plexiform layers of the retina (at protein level) (PubMed:22137173). Expressed in monocytes and macrophages (PubMed:25725101). {ECO:0000269|PubMed:22137173, ECO:0000269|PubMed:25725101}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs387906795 rs387906796 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:8300559}. Cell membrane {ECO:0000250|UniProtKB:P97391}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:P97391}. Recycling endosome {ECO:0000250|UniProtKB:P97391}. Golgi apparatus, cis-Golgi network {ECO:0000250|UniProtKB:P97391}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:P97391}. |
| Mouse PG classification | NA |
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