| Gene Information | |
|---|---|
| Gene Name | ZFP36 |
| Organism | Homo sapiens (Human) |
| Gene Length | 326 |
| Protein Names | mRNA decay activator protein ZFP36 (G0/G1 switch regulatory protein 24) (Growth factor-inducible nuclear protein NUP475) (Tristetraprolin) (Zinc finger protein 36) (Zfp-36) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000128016 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P26651 |
| Gene Card | ZFP36 |
| Uniprot ID | P26651 |
| Pfam | PF00642 |
| In ASD | no |
| Allosteric Prediction | no (-0.728494389) |
| Ortholog in Animals | Alpaca_ ZFP36 ( ortholog_one2one ) Dog_ ZFP36 ( ortholog_one2one ) GuineaPig_ ZFP36 ( ortholog_one2one ) Macaque_ ZFP36 ( ortholog_one2one ) Mouse_ Zfp36 ( ortholog_one2one ) Pig_ ZFP36 ( ortholog_one2one ) Rat_ Zfp36 ( ortholog_one2one ) Rabbit_ ZFP36 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ZFP36L1, ZFP36L2 |
| Tissue | NA |
| Tissue Specificity | Expressed in both basal and suprabasal epidermal layers (PubMed:27182009). Expressed in epidermal keratinocytes (PubMed:27182009). Expressed strongly in mature dendritic cells (PubMed:18367721). Expressed in immature dendritic cells (at protein level) (PubMed:18367721). {ECO:0000269|PubMed:18367721, ECO:0000269|PubMed:27182009}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.011111(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 4J8S (X-ray 1.55A ) |
| DBSNP | rs17878633 rs2229272 rs17886974 rs17884899 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:15014438, ECO:0000269|PubMed:27182009}. Cytoplasm {ECO:0000269|PubMed:10330172, ECO:0000269|PubMed:12115244, ECO:0000269|PubMed:14766228, ECO:0000269|PubMed:15014438, ECO:0000269|PubMed:20221403}. Cytoplasmic granule {ECO:0000269|PubMed:15014438}. Cytoplasm, P-body {ECO:0000269|PubMed:17369404}. Note=Shuttles between nucleus and cytoplasm in a CRM1-dependent manner (By similarity). Localized predominantly in the cytoplasm in a p38 MAPK- and YWHAB-dependent manner (By similarity). Colocalizes with SH3KBP1 and MAP3K4 in the cytoplasm (PubMed:20221403). Component of cytoplasmic stress granules (SGs) (By similarity). Localizes to cytoplasmic stress granules upon energy starvation (PubMed:15014438). Localizes in processing bodies (PBs) (PubMed:17369404). Excluded from stress granules in a phosphorylation MAPKAPK2-dependent manner (By similarity). Shuttles in and out of both cytoplasmic P-body and SGs (By similarity). {ECO:0000250|UniProtKB:P22893, ECO:0000269|PubMed:15014438, ECO:0000269|PubMed:17369404, ECO:0000269|PubMed:20221403}.; Nucleus {ECO:0000269|PubMed:14679154}. Cytoplasm {ECO:0000269|PubMed:14679154}. Note=(Microbial infection) Colocalizes with HTLV-1 TAX in the nucleus and the cytoplasm in a region surrounding the nucleus. {ECO:0000269|PubMed:14679154}. |
| Mouse PG classification | NA |
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