| Gene Information | |
|---|---|
| Gene Name | KARS |
| Organism | Homo sapiens (Human) |
| Gene Length | 597 |
| Protein Names | Lysine--tRNA ligase (EC 2.7.7.-) (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS) |
| Target Name | lysine--trna ligase |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q15046 |
| Gene Card | KARS1 |
| Uniprot ID | Q15046 |
| Pfam | PF00152; PF01336 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.049259(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3BJU (X-ray 2.31A ) 4DPG (X-ray 2.84A ) 4YCU (X-ray 2.10A ) 4YCW (X-ray 2.90A ) 6CHD (X-ray 2.50A ) 6ILD (X-ray 1.88A ) 6ILH (X-ray 2.50A ) 7EA9 (X-ray 2.50A ) |
| DBSNP | rs369114426 rs267607194 rs397514745 rs11557665 rs772410450 rs146955132 rs397514746 rs761527468 rs778748895 rs1555512658 rs770522582 rs6834 |
| Subcellular location [CC] | [Isoform Cytoplasmic]: Cytoplasm, cytosol {ECO:0000269|PubMed:10952987, ECO:0000269|PubMed:19289464, ECO:0000269|PubMed:23159739, ECO:0000269|PubMed:28887846}. Cytoplasm {ECO:0000269|PubMed:15220430}. Nucleus {ECO:0000269|PubMed:15220430, ECO:0000269|PubMed:23159739}. Cell membrane {ECO:0000269|PubMed:15220430}; Peripheral membrane protein {ECO:0000269|PubMed:15220430}. Secreted {ECO:0000269|PubMed:15851690}. Note=Secretion is induced by TNF-alpha (PubMed:15851690). Cytosolic in quiescent mast cells. Translocates into the nucleus in response to mast cell activation by immunoglobulin E (PubMed:23159739). {ECO:0000269|PubMed:15851690, ECO:0000269|PubMed:23159739}.; [Isoform Mitochondrial]: Mitochondrion {ECO:0000269|PubMed:10952987}. |
| Mouse PG classification | LPG |
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