| Gene Information | |
|---|---|
| Gene Name | LARGE1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 756 |
| Protein Names | Xylosyl- and glucuronyltransferase LARGE1 (EC 2.4.-.-) (Acetylglucosaminyltransferase-like 1A) (Glycosyltransferase-like protein) (LARGE xylosyl- and glucuronyltransferase 1) [Includes: Alpha-1,3-xylosyltransferase LARGE1 (EC 2.4.2.-); Beta-1,3-glucuronyltransferase LARGE1 (EC 2.4.1.-)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000133424 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O95461 |
| Gene Card | LARGE1 |
| Uniprot ID | O95461 |
| Pfam | PF01501 |
| In ASD | no |
| Allosteric Prediction | no (-1.069636874) |
| Ortholog in Animals | Alpaca_ LARGE1 ( ortholog_one2one ) Dog_ LARGE1 ( ortholog_one2one ) GuineaPig_ LARGE1 ( ortholog_one2one ) Macaque_ LARGE1 ( ortholog_one2one ) Mouse_ Large1 ( ortholog_one2one ) Pig_ LARGE1 ( ortholog_one2one ) Rat_ Large1 ( ortholog_one2one ) Rabbit_ LARGE1 ( ortholog_one2one ) |
| Ohnologs | LARGE2 |
| Paralogs | B4GAT1, GXYLT2, XXYLT1, LARGE2, GXYLT1 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Highest expression in heart, brain and skeletal muscle. {ECO:0000269|PubMed:15752776}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs470035 rs135311 rs267607210 rs267607209 rs121908675 rs1046166 |
| Subcellular location [CC] | Golgi apparatus membrane {ECO:0000269|PubMed:15661757, ECO:0000269|PubMed:15958417, ECO:0000269|PubMed:25279699}; Single-pass type II membrane protein {ECO:0000269|PubMed:15661757, ECO:0000269|PubMed:15958417}. |
| Mouse PG classification | NA |
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