| Gene Information | |
|---|---|
| Gene Name | GRIA3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 894 |
| Protein Names | Glutamate receptor 3 (GluR-3) (AMPA-selective glutamate receptor 3) (GluR-C) (GluR-K3) (Glutamate receptor ionotropic, AMPA 3) (GluA3) |
| Target Name | glutamate receptor ampa 3 |
| Target Type | Successful target |
| Gene Age | 950 ( ENSG00000125675 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P42263 |
| Gene Card | GRIA3 |
| Uniprot ID | P42263 |
| Pfam | PF01094; PF00060; PF10613 |
| In ASD | yes |
| Allosteric Prediction | yes (1.292683668) |
| Ortholog in Animals | Alpaca_ GRIA3 ( ortholog_one2one ) Dog_ GRIA3 ( ortholog_one2one ) GuineaPig_ GRIA3 ( ortholog_one2one ) Macaque_ GRIA3 ( ortholog_one2one ) Mouse_ Gria3 ( ortholog_one2one ) Pig_ GRIA3 ( ortholog_one2one ) Rat_ Gria3 ( ortholog_one2one ) Rabbit_ GRIA3 ( ortholog_one2one ) |
| Ohnologs | GRIA2, GRIA4, GRIA1 |
| Paralogs | GRIN3A, GRIN2A, GRIK5, GRIN2C, GRID1, GRID2, GRIK3, GRIN2D, GRIN1, GRIK4, GRIK1, GRIA2, GRIA1, GRIN3B, GRIK2, GRIA4, GRIN2B |
| Tissue | cerebral.cortex, amygdala, caudate.nucleus, hippocampus, nucleus.accumbens, putamen, substantia.nigra |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002101(Rat);0.36275(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs757586471 rs368568228 rs1052538 rs137852351 rs137852352 rs137852350 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. Note=Interaction with CNIH2 and CNIH3 promotes cell surface expression. {ECO:0000250}. |
| Mouse PG classification | NA |
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