| Gene Information | |
|---|---|
| Gene Name | MIF |
| Organism | Homo sapiens (Human) |
| Gene Length | 115 |
| Protein Names | Macrophage migration inhibitory factor (MIF) (EC 5.3.2.1) (Glycosylation-inhibiting factor) (GIF) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase) |
| Target Name | macrophage migration inhibitory factor |
| Target Type | Clinical trial target |
| Gene Age | 950 ( ENSG00000240972 ) 3 ( ENSG00000276701 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P14174 |
| Gene Card | MIF |
| Uniprot ID | P14174 |
| Pfam | PF01187 |
| In ASD | yes |
| Allosteric Prediction | yes (0.924229754) |
| Ortholog in Animals | Alpaca_ MIF ( ortholog_one2one ) Dog_ MIF ( ortholog_one2one ) GuineaPig_ MIF ( ortholog_one2one ) Mouse_ Mif ( ortholog_one2one ) Pig_ MIF ( ortholog_one2one ) Rat_ AABR07064983.2 ( ortholog_one2many ) Rat_ AABR07061532.1 ( ortholog_one2many ) Rat_ AABR07030647.1 ( ortholog_one2many ) Rat_ AABR07016805.1 ( ortholog_one2many ) Rat_ Mif ( ortholog_one2many ) Rat_ AC127887.1 ( ortholog_one2many ) Rabbit_ MIF ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DDT, DDTL |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1CA7 (X-ray 2.50A ) 1CGQ (X-ray 2.00A ) 1GCZ (X-ray 1.90A ) 1GD0 (X-ray 1.50A ) 1GIF (X-ray 1.90A ) 1LJT (X-ray 2.00A ) 1MIF (X-ray 2.60A ) 1P1G (X-ray 2.50A ) 2OOH (X-ray 1.85A ) 2OOW (X-ray 1.75A ) 2OOZ (X-ray 1.80A ) 3B9S (X-ray 1.80A ) 3CE4 (X-ray 1.55A ) 3DJH (X-ray 1.25A ) 3DJI (X-ray 1.95A ) 3HOF (X-ray 1.90A ) 3IJG (X-ray 1.70A ) 3IJJ (X-ray 1.25A ) 3JSF (X-ray 1.93A ) 3JSG (X-ray 1.58A ) 3JTU (X-ray 1.86A ) 3L5P (X-ray 1.80A ) 3L5R (X-ray 1.94A ) 3L5S (X-ray 1.86A ) 3L5T (X-ray 1.86A ) 3L5U (X-ray 1.90A ) 3L5V (X-ray 1.70A ) 3SMB (X-ray 1.60A ) 3SMC (X-ray 1.80A ) 3U18 (X-ray 1.90A ) 3WNR (X-ray 2.01A ) 3WNS (X-ray 1.66A ) 3WNT (X-ray 2.07A ) 4ETG (X-ray 1.61A ) 4EUI (X-ray 1.70A ) 4EVG (X-ray 1.70A ) 4F2K (X-ray 1.53A ) 4GRN (X-ray 1.25A ) 4GRO (X-ray 2.00A ) 4GRP (X-ray 1.27A ) 4GRQ (X-ray 1.65A ) 4GRR (X-ray 1.47A ) 4GRU (X-ray 1.92A ) 4GUM (X-ray 2.33A ) 4K9G (X-ray 1.55A ) 4OSF (X-ray 1.62A ) 4OYQ (X-ray 1.70A ) 4P01 (X-ray 2.07A ) 4P0H (X-ray 1.93A ) 4PKK (X-ray 1.78A ) 4PKZ (X-ray 1.90A ) 4PLU (X-ray 1.63A ) 4TRF (X-ray 1.63A ) 4TRU (X-ray 1.81A ) 4WR8 (X-ray 2.60A ) 4WRB (X-ray 1.81A ) 4XX7 (X-ray 1.77A ) 4XX8 (X-ray 1.77A ) 4Z15 (X-ray 1.60A ) 4Z1T (X-ray 1.50A ) 4Z1U (X-ray 2.05A ) 5B4O (X-ray 1.37A ) 5BS9 (X-ray 1.98A ) 5BSC (X-ray 1.89A ) 5BSI (X-ray 2.00A ) 5BSJ (X-ray 2.00A ) 5EIZ (X-ray 1.96A ) 5HVS (X-ray 1.75A ) 5HVT (X-ray 1.75A ) 5HVV (X-ray 1.90A ) 5J7P (X-ray 1.85A ) 5J7Q (X-ray 2.05A ) 5UMJ (X-ray 1.61A ) 5UMK (X-ray 1.73A ) 5UZY (X-ray 1.71A ) 5V70 (X-ray 1.94A ) 5V73 (X-ray 1.68A ) 5XEJ (X-ray 2.50A ) 6B1C (X-ray 2.16A ) 6B1K (X-ray 1.17A ) 6B2C (X-ray 2.00A ) 6BG6 (X-ray 1.52A ) 6BG7 (X-ray 2.54A ) 6CB5 (X-ray 1.78A ) 6CBF (X-ray 2.30A ) 6CBG (X-ray 2.00A ) 6CBH (X-ray 2.00A ) 6FVE (X-ray 1.41A ) 6FVH (X-ray 1.40A ) 6OY8 (X-ray 1.53A ) 6OYB (X-ray 1.53A ) 6OYE (X-ray 1.53A ) 6OYG (X-ray 1.55A ) 6PEG (X-ray 2.00A ) 7KQX (X-ray 1.60A ) |
| DBSNP | NA |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:15908412, ECO:0000269|PubMed:19454686, ECO:0000269|PubMed:2552447, ECO:0000269|PubMed:8234256}. Cytoplasm {ECO:0000269|PubMed:11089976, ECO:0000269|PubMed:19454686}. Note=Does not have a cleavable signal sequence and is secreted via a specialized, non-classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens. {ECO:0000269|PubMed:15908412}. |
| Mouse PG classification | NA |
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