| Gene Information | |
|---|---|
| Gene Name | MIEN1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 115 |
| Protein Names | Migration and invasion enhancer 1 (HBV X-transactivated gene 4 protein) (HBV XAg-transactivated protein 4) (Protein C35) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000141741 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9BRT3 |
| Gene Card | MIEN1 |
| Uniprot ID | Q9BRT3 |
| Pfam | PF10262 |
| In ASD | no |
| Allosteric Prediction | no (-1.259479166) |
| Ortholog in Animals | Alpaca_ MIEN1 ( ortholog_one2one ) Dog_ MIEN1 ( ortholog_one2one ) GuineaPig_ MIEN1 ( ortholog_one2one ) Mouse_ Mien1 ( ortholog_one2one ) Pig_ MIEN1 ( ortholog_one2one ) Rat_ Mien1 ( ortholog_one2one ) Rabbit_ MIEN1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SELENOW, SELENOV |
| Tissue | NA |
| Tissue Specificity | Among normal tissues, present only in Leydig cells. Strongly up-regulated in breast cancers and in brain cancer distant metastasis (at protein level). Up-regulated in prostate cancer cells and in the higher grades of prostate adenocarcinoma (at protein level). {ECO:0000269|PubMed:17121940, ECO:0000269|PubMed:19503095}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2LJK (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, cytosol. Cell membrane; Lipid-anchor; Cytoplasmic side. Note=Concentrates at the leading edge of migrating cells. Localizes outside membrane raft regions. |
| Mouse PG classification | NA |
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