Gene Information
Gene NameZFP36L1
OrganismHomo sapiens (Human)
Gene Length338
Protein NamesmRNA decay activator protein ZFP36L1 (Butyrate response factor 1) (EGF-response factor 1) (ERF-1) (TPA-induced sequence 11b) (Zinc finger protein 36, C3H1 type-like 1) (ZFP36-like 1)
Target NameNA
Target TypeNA
Gene Age544 ( ENSG00000185650 )
Evolutionary StageEukaryota
AlphaFoldDBQ07352
Gene CardZFP36L1
Uniprot IDQ07352
PfamPF04553; PF00642
In ASDno
Allosteric Predictionno (-0.289321071)
Ortholog in AnimalsAlpaca_ ZFP36L1 ( ortholog_one2one )
Dog_ ZFP36L1 ( ortholog_one2one )
GuineaPig_ ZFP36L1 ( ortholog_one2one )
Macaque_ ZFP36L1 ( ortholog_one2one )
Mouse_ Zfp36l1 ( ortholog_one2one )
Pig_ ZFP36L1 ( ortholog_one2one )
Rat_ Zfp36l1 ( ortholog_one2one )
OhnologsZFP36L2
ParalogsZFP36, ZFP36L2
TissueNA
Tissue SpecificityExpressed mainly in the basal epidermal layer, weakly in the suprabasal epidermal layers (PubMed:27182009). Expressed in epidermal keratinocytes (at protein level) (PubMed:27182009). Expressed in osteoblasts (PubMed:15465005). {ECO:0000269|PubMed:15465005, ECO:0000269|PubMed:27182009}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1W0V  (X-ray  2.27A  )  1W0W  (X-ray  2.11A  ) 
DBSNP NA 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:12198173}. Cytoplasm {ECO:0000269|PubMed:12198173}. Cytoplasmic granule {ECO:0000269|PubMed:15967811}. Cytoplasm, P-body {ECO:0000269|PubMed:15967811, ECO:0000269|PubMed:17369404}. Note=Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner (By similarity). Component of cytoplasmic stress granules (PubMed:15967811). Localizes in processing bodies (PBs) (PubMed:17369404). {ECO:0000250|UniProtKB:P23950, ECO:0000269|PubMed:15967811, ECO:0000269|PubMed:17369404}.
Mouse PG classificationNA
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