Gene Information
Gene NameMICA
OrganismHomo sapiens (Human)
Gene Length383
Protein NamesMHC class I polypeptide-related sequence A (MIC-A)
Target NameNA
Target TypeNA
Gene Age3 ( ENSG00000183214 )
544 ( ENSG00000204520 )
3 ( ENSG00000231225 )
3 ( ENSG00000233051 )
3 ( ENSG00000235233 )
Evolutionary StageVertebrata
AlphaFoldDBQ29983
Gene CardMICA
Uniprot IDQ29983
PfamPF07654; PF00129
In ASDno
Allosteric Predictionno (-0.696821103)
Ortholog in AnimalsAlpaca_ MICB ( ortholog_one2one )
Mouse_ Mill1 ( ortholog_many2many )
Mouse_ Mill2 ( ortholog_many2many )
Rat_ Mill1 ( ortholog_many2many )
Rat_ Micb ( ortholog_many2many )
OhnologsNA
ParalogsHLA-B, HLA-E, HLA-A, HLA-F, HLA-G, HLA-C, CD1B, ULBP2, RAET1L, FCGRT, RAET1G, CD1A, CD1D, CD1C, RAET1E, ULBP3, ULBP1, CD1E, MICB, AZGP1, HFE, MR1
TissueNA
Tissue SpecificityWidely expressed with the exception of the central nervous system where it is absent. Expressed predominantly in gastric epithelium and also in monocytes, keratinocytes, endothelial cells, fibroblasts and in the outer layer of Hassal's corpuscles within the medulla of normal thymus. In skin, expressed mainly in the keratin layers, basal cells, ducts and follicles. Also expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In thyomas, overexpressed in cortical and medullar epithelial cells. Tumors expressing MICA display increased levels of gamma delta T-cells. {ECO:0000269|PubMed:10359807, ECO:0000269|PubMed:10363723, ECO:0000269|PubMed:10691930, ECO:0000269|PubMed:12902493, ECO:0000269|PubMed:17565371, ECO:0000269|PubMed:8901601, ECO:0000269|PubMed:9396860}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1B3J  (X-ray  3.00A  )  1HYR  (X-ray  2.70A  )  7FI5  (X-ray  2.39A  )  7FI6  (X-ray  2.90A  )  7FI7  (X-ray  2.78A  )  7FI8  (X-ray  2.80A  )  7FI9  (X-ray  2.16A  ) 
DBSNP rs9380254  rs1063630  rs1051785  rs17200158  rs1051786  rs41558312  rs41557113  rs41556715  rs1051790  rs41539919  rs1051791  rs1051792  rs3819269  rs41560824  rs3819268  rs1051794  rs1131896  rs41549718  rs1131897  rs1131898  rs41546915  rs1051798  rs1140700  rs1051799  rs41540613  rs72558175  rs1063635  rs41557614  rs61759927  rs41553616  rs72558178  rs41554412  rs41546114  rs9266825  rs41545814  rs1882 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:10363723, ECO:0000269|PubMed:18287244, ECO:0000269|PubMed:8901601};
Single-pass type I membrane protein {ECO:0000269|PubMed:10363723, ECO:0000269|PubMed:18287244, ECO:0000269|PubMed:8901601}. Cytoplasm {ECO:0000269|PubMed:10363723, ECO:0000269|PubMed:18287244, ECO:0000269|PubMed:8901601}. Note=Expressed on the cell surface in gastric epithelium, endothelial cells and fibroblasts and in the cytoplasm in keratinocytes and monocytes. Infection with human adenovirus 5 suppresses cell surface expression due to the adenoviral E3-19K protein which causes retention in the endoplasmic reticulum. {ECO:0000269|PubMed:10363723, ECO:0000269|PubMed:18287244, ECO:0000269|PubMed:8901601}.
Mouse PG classificationNA
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