| Gene Information | |
|---|---|
| Gene Name | CSPG4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2322 |
| Protein Names | Chondroitin sulfate proteoglycan 4 (Chondroitin sulfate proteoglycan NG2) (Melanoma chondroitin sulfate proteoglycan) (Melanoma-associated chondroitin sulfate proteoglycan) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000173546 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q6UVK1 |
| Gene Card | CSPG4 |
| Uniprot ID | Q6UVK1 |
| Pfam | PF00054; PF02210 |
| In ASD | no |
| Allosteric Prediction | no (-1.000182936) |
| Ortholog in Animals | Alpaca_ CSPG4 ( ortholog_one2one ) Dog_ CSPG4 ( ortholog_one2one ) GuineaPig_ CSPG4 ( ortholog_one2one ) Macaque_ CSPG4 ( ortholog_one2one ) Mouse_ Cspg4 ( ortholog_one2one ) Pig_ CSPG4 ( ortholog_one2one ) Rat_ Cspg4 ( ortholog_one2one ) Rabbit_ CSPG4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Detected only in malignant melanoma cells. {ECO:0000269|PubMed:8790396}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);0.001000(Rat);0.033333(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7ML7 (EM 3.17A ) 7N8X (EM 3.40A ) 7N9Y (EM 4.80A ) |
| DBSNP | rs8023621 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:Q00657}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q00657}; Extracellular side {ECO:0000250|UniProtKB:Q00657}. Apical cell membrane {ECO:0000250|UniProtKB:Q00657}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q00657}; Extracellular side {ECO:0000250|UniProtKB:Q00657}. Cell projection, lamellipodium membrane {ECO:0000250|UniProtKB:Q00657}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q00657}; Extracellular side {ECO:0000250|UniProtKB:Q00657}. Cell surface {ECO:0000250|UniProtKB:Q00657}. Note=Localized at the apical plasma membrane it relocalizes to the lamellipodia of astrocytoma upon phosphorylation by PRKCA. Localizes to the retraction fibers. Localizes to the plasma membrane of oligodendrocytes (By similarity). {ECO:0000250|UniProtKB:Q00657, ECO:0000250|UniProtKB:Q8VHY0}. |
| Mouse PG classification | NA |
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