| Gene Information | |
|---|---|
| Gene Name | MHS3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1103 |
| Protein Names | Voltage-dependent calcium channel subunit alpha-2/delta-1 (Voltage-gated calcium channel subunit alpha-2/delta-1) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-1; Voltage-dependent calcium channel subunit delta-1] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P54289 |
| Gene Card | CACNA2D1 |
| Uniprot ID | P54289 |
| Pfam | PF08473; PF13768; PF08399 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Isoform 1 is expressed in skeletal muscle. Isoform 2 is expressed in the central nervous system. Isoform 2, isoform 4 and isoform 5 are expressed in neuroblastoma cells. Isoform 3, isoform 4 and isoform 5 are expressed in the aorta. {ECO:0000269|PubMed:1309651, ECO:0000269|PubMed:8107964}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7MIX (EM 3.00A ) 7MIY (EM 3.10A ) 7UHF (EM 3.10A ) 7UHG (EM 3.00A ) 7VFS (EM 2.80A ) 7VFU (EM 3.00A ) 7VFV (EM 3.00A ) 7VFW (EM 3.30A ) |
| DBSNP | rs9886043 rs35131433 |
| Subcellular location [CC] | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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