| Gene Information | |
|---|---|
| Gene Name | PTPRC |
| Organism | Homo sapiens (Human) |
| Gene Length | 1306 |
| Protein Names | Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45) |
| Target Name | leukocyte common antigen |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000081237 ) 3 ( ENSG00000262418 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P08575 |
| Gene Card | PTPRC |
| Uniprot ID | P08575 |
| Pfam | PF12567; PF00041; PF12453; PF00102 |
| In ASD | yes |
| Allosteric Prediction | yes (1.00033624) |
| Ortholog in Animals | Alpaca_ PTPRC ( ortholog_one2one ) Dog_ PTPRC ( ortholog_one2one ) GuineaPig_ PTPRC ( ortholog_one2one ) Macaque_ PTPRC ( ortholog_one2one ) Mouse_ Ptprc ( ortholog_one2one ) Pig_ PTPRC ( ortholog_one2one ) Rat_ Ptprc ( ortholog_one2one ) Rabbit_ PTPRC ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PTPN12, PTPN6, PTPN18, PTPN7, PTPN1, PTPN13, PTPRF, PTPRK, PTPRB, PTPRA, PTPN22, PTPRG, PTPRR, PTPN5, PTPN23, PTPRZ1, PTPN9, PTPRE, PTPN4, PTPRT, PTPRS, PTPRD, PTPN2, PTPRO, PTPRJ, PTPRM, PTPN11, PTPN20, PTPRU, PTPN14, PTPN3, PTPRN, PTPRN2, PTPRH, PTPN21 |
| Tissue | whole.blood |
| Tissue Specificity | Isoform 1: Detected in thymocytes. Isoform 2: Detected in thymocytes. Isoform 3: Detected in thymocytes. Isoform 4: Not detected in thymocytes. Isoform 5: Detected in thymocytes. Isoform 6: Not detected in thymocytes. Isoform 7: Detected in thymocytes. Isoform 8: Not detected in thymocytes. {ECO:0000269|PubMed:11975983}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001823(Rat);0.016667(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 1YGR (X-ray 2.90A ) 1YGU (X-ray 2.90A ) 5FMV (X-ray 2.90A ) 5FN6 (X-ray 3.30A ) 5FN7 (X-ray 2.30A ) |
| DBSNP | rs4915154 rs2230606 rs6696162 rs12136658 rs2298872 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:12676959, ECO:0000269|PubMed:22174689}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:12676959}. Note=Colocalized with DPP4 in membrane rafts. {ECO:0000269|PubMed:12676959}. |
| Mouse PG classification | NA |
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