| Gene Information | |
|---|---|
| Gene Name | SIM1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 766 |
| Protein Names | Single-minded homolog 1 (Class E basic helix-loop-helix protein 14) (bHLHe14) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000112246 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P81133 |
| Gene Card | SIM1 |
| Uniprot ID | P81133 |
| Pfam | PF00010; PF00989; PF08447; PF06621 |
| In ASD | no |
| Allosteric Prediction | no (-0.521057503) |
| Ortholog in Animals | Alpaca_ SIM1 ( ortholog_one2one ) Dog_ SIM1 ( ortholog_one2one ) GuineaPig_ SIM1 ( ortholog_one2one ) Macaque_ SIM1 ( ortholog_one2one ) Mouse_ Sim1 ( ortholog_one2one ) Pig_ SIM1 ( ortholog_one2one ) Rat_ Sim1 ( ortholog_one2one ) Rabbit_ SIM1 ( ortholog_one2one ) |
| Ohnologs | NPAS3, SIM2 |
| Paralogs | EPAS1, NPAS1, SIM2, NPAS4, HIF1A, NPAS3, HIF3A |
| Tissue | kidney |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.004323(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs438766 rs3734354 rs3734355 |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00632, ECO:0000255|PROSITE-ProRule:PRU00981}. |
| Mouse PG classification | NA |
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