Gene Information
Gene NameTRPV6
OrganismHomo sapiens (Human)
Gene Length765
Protein NamesTransient receptor potential cation channel subfamily V member 6 (TrpV6) (CaT-like) (CaT-L) (Calcium transport protein 1) (CaT1) (Epithelial calcium channel 2) (ECaC2)
Target Nametransient receptor potential cation channel v6
Target TypeClinical trial target
Gene Age680 ( ENSG00000165125 )
3 ( ENSG00000276971 )
Evolutionary StageEumetazoa
AlphaFoldDBQ9H1D0
Gene CardTRPV6
Uniprot IDQ9H1D0
PfamPF00023; PF12796; PF00520
In ASDno
Allosteric Predictionyes (0.356272862)
Ortholog in AnimalsAlpaca_ TRPV6 ( ortholog_one2one )
Dog_ TRPV6 ( ortholog_one2one )
GuineaPig_ TRPV6 ( ortholog_one2one )
Macaque_ TRPV6 ( ortholog_one2one )
Mouse_ Trpv6 ( ortholog_one2one )
Pig_ TRPV6 ( ortholog_one2one )
Rat_ Trpv6 ( ortholog_one2one )
Rabbit_ TRPV6 ( ortholog_one2one )
OhnologsTRPV4, TRPV3, TRPV2, TRPV1
ParalogsTRPV4, TRPV3, TRPV2, TRPV5, TRPV1
Tissueduodenum, gall.bladder, pancreas, placenta, prostate, salivary.gland, small.intestine
Tissue SpecificityExpressed at high levels in the gastrointestinal tract, including esophagus, stomach, duodenum, jejunum, ileum and colon, and in pancreas, placenta, prostate and salivary gland. Expressed at moderate levels in liver, kidney and testis. Expressed in trophoblasts of placenta villus trees (at protein level)(PubMed:23612980). Expressed in locally advanced prostate cancer, metastatic and androgen-insensitive prostatic lesions but not detected in healthy prostate tissue and benign prostatic hyperplasia. {ECO:0000269|PubMed:11097838, ECO:0000269|PubMed:11278579, ECO:0000269|PubMed:23612980}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.002990(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6BO8  (EM  3.60A  )  6BO9  (EM  4.00A  )  6BOA  (EM  4.20A  )  6D7S  (EM  4.34A  )  6D7T  (EM  4.44A  )  6E2F  (EM  3.90A  )  7K4A  (EM  3.26A  )  7K4B  (EM  3.10A  )  7K4C  (EM  3.78A  )  7K4D  (EM  3.66A  )  7K4E  (EM  4.34A  )  7K4F  (EM  3.75A  )  7S88  (EM  2.69A  )  7S89  (EM  2.54A  )  7S8B  (EM  2.43A  )  7S8C  (EM  2.85A  ) 
DBSNP rs17881456  rs4987657  rs1586190048  rs529924080  rs4987665  rs4987667  rs1281361203  rs755916513  rs4987682 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:11097838, ECO:0000269|PubMed:11248124, ECO:0000269|PubMed:11278579, ECO:0000269|PubMed:15184369, ECO:0000269|PubMed:23612980, ECO:0000269|PubMed:29258289, ECO:0000269|PubMed:29861107};
Multi-pass membrane protein {ECO:0000269|PubMed:29258289}.
Mouse PG classificationNA
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