| Gene Information | |
|---|---|
| Gene Name | NXF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 619 |
| Protein Names | Nuclear RNA export factor 1 (Tip-associated protein) (Tip-associating protein) (mRNA export factor TAP) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000162231 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q9UBU9 |
| Gene Card | NXF1 |
| Uniprot ID | Q9UBU9 |
| Pfam | PF02136; PF09162; PF03943 |
| In ASD | no |
| Allosteric Prediction | no (-0.619237417) |
| Ortholog in Animals | Alpaca_ NXF1 ( ortholog_one2one ) Dog_ NXF1 ( ortholog_one2one ) GuineaPig_ NXF1 ( ortholog_one2one ) Macaque_ NXF1 ( ortholog_one2one ) Mouse_ Nxf1 ( ortholog_one2one ) Pig_ NXF1 ( ortholog_one2one ) Rat_ Nxf1 ( ortholog_one2one ) Rabbit_ NXF1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NXF2, NXF2B, NXF3 |
| Tissue | NA |
| Tissue Specificity | Expressed ubiquitously. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1FO1 (X-ray 2.90A ) 1FT8 (X-ray 3.15A ) 1GO5 (NMR - ) 1JKG (X-ray 1.90A ) 1JN5 (X-ray 2.80A ) 1KOH (X-ray 3.80A ) 1KOO (X-ray 3.80A ) 1OAI (X-ray 1.00A ) 2Z5K (X-ray 2.60A ) 2Z5M (X-ray 3.00A ) 3RW6 (X-ray 2.30A ) 3RW7 (X-ray 3.00A ) 4WYK (X-ray 3.40A ) 6E5U (X-ray 3.80A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:19864460, ECO:0000269|PubMed:23591820, ECO:0000269|PubMed:25662211}. Nucleus, nucleoplasm {ECO:0000269|PubMed:19324961, ECO:0000269|PubMed:23826332}. Nucleus speckle {ECO:0000269|PubMed:19324961, ECO:0000269|PubMed:23826332}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:23591820}. Nucleus envelope {ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:23591820}. Cytoplasm {ECO:0000269|PubMed:10924507, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:19324961, ECO:0000269|PubMed:19864460}. Cytoplasm, Stress granule {ECO:0000269|PubMed:18596238}. Note=Localized predominantly in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex. Shuttles between the nucleus and the cytoplasm. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. The association with the TREX complex seems to occur in regions surrounding nuclear speckles known as perispeckles (PubMed:23826332). Nucleus; nuclear rim (PubMed:25662211). {ECO:0000269|PubMed:23826332, ECO:0000269|PubMed:25662211}. |
| Mouse PG classification | NA |
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