| Gene Information | |
|---|---|
| Gene Name | TRDMT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 391 |
| Protein Names | tRNA (cytosine(38)-C(5))-methyltransferase (EC 2.1.1.204) (DNA (cytosine-5)-methyltransferase-like protein 2) (Dnmt2) (DNA methyltransferase homolog HsaIIP) (DNA MTase homolog HsaIIP) (M.HsaIIP) (PuMet) |
| Target Name | trna (cytosine(38)-c(5))-methyltransferase |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000107614 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | O14717 |
| Gene Card | TRDMT1 |
| Uniprot ID | O14717 |
| Pfam | PF00145 |
| In ASD | no |
| Allosteric Prediction | yes (0.231986347) |
| Ortholog in Animals | Alpaca_ TRDMT1 ( ortholog_one2one ) Dog_ TRDMT1 ( ortholog_one2one ) GuineaPig_ TRDMT1 ( ortholog_one2one ) Macaque_ TRDMT1 ( ortholog_one2one ) Mouse_ Trdmt1 ( ortholog_one2one ) Pig_ TRDMT1 ( ortholog_one2one ) Rat_ Trdmt1 ( ortholog_one2one ) Rabbit_ TRDMT1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DNMT1 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Higher expression in testis, ovary and thymus and at much lower levels in spleen, prostate, colon, small intestine, and peripheral blood leukocytes. |
| Pharmacological Animal Models | 0.087880(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1G55 (X-ray 1.80A ) |
| DBSNP | rs11254413 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:16424344}. |
| Mouse PG classification | NA |
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