| Gene Information | |
|---|---|
| Gene Name | EPHB2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1055 |
| Protein Names | Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2] |
| Target Name | ephrin type-b receptor 2 |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000133216 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P29323 |
| Gene Card | EPHB2 |
| Uniprot ID | P29323 |
| Pfam | PF14575; PF01404; PF07699; PF00041; PF07714; PF00536 |
| In ASD | no |
| Allosteric Prediction | yes (0.943368899) |
| Ortholog in Animals | Alpaca_ EPHB2 ( ortholog_one2one ) Dog_ EPHB2 ( ortholog_one2one ) GuineaPig_ EPHB2 ( ortholog_one2one ) Macaque_ EPHB2 ( ortholog_one2one ) Mouse_ Ephb2 ( ortholog_one2one ) Pig_ EPHB2 ( ortholog_one2one ) Rat_ Ephb2 ( ortholog_one2one ) Rabbit_ EPHB2 ( ortholog_one2one ) |
| Ohnologs | EPHA3, EPHA6, EPHB6, EPHA4, EPHA7, EPHA1, EPHB1, EPHB3, EPHB4 |
| Paralogs | EPHA7, NTRK1, EPHB3, ALK, FGFR3, EPHA2, LMTK2, EPHB1, EPHA3, INSR, PDGFRA, EGFR, CSF1R, ERBB3, KIT, NTRK3, DDR1, ERBB4, EPHA8, TEK, MUSK, MERTK, FGFR4, FLT3, EPHB6, FLT1, DDR2, EPHA6, NTRK2, IGF1R, INSRR, EPHB4, PDGFRB, ERBB2, KDR, EPHA5, FGFR2, TYRO3, MST1R, AXL, ROR1, ROR2, ROS1, EPHA10, EPHA4, RET, LTK, FLT4, TIE1, FGFR1, RYK, EPHA1, MET |
| Tissue | NA |
| Tissue Specificity | Brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially expressed in fetal brain. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002419(Rat);0.028571(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1B4F (X-ray 1.95A ) 1F0M (X-ray 2.20A ) 2QBX (X-ray 2.30A ) 3ZFM (X-ray 2.27A ) |
| DBSNP | rs201754821 rs35882952 rs56180036 rs142173175 rs28936395 rs761749948 rs55826626 rs372653137 |
| Subcellular location [CC] | Cell membrane; Single-pass type I membrane protein. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. |
| Mouse PG classification | NA |
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