Gene Information
Gene NameZFHX3
OrganismHomo sapiens (Human)
Gene Length3703
Protein NamesZinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3)
Target NameNA
Target TypeNA
Gene Age680 ( ENSG00000140836 )
Evolutionary StageEumetazoa
AlphaFoldDBNA
Gene CardZFHX3
Uniprot IDQ15911
PfamPF00046; PF00096
In ASDno
Allosteric Predictionno (-0.644936107)
Ortholog in AnimalsAlpaca_ ZFHX3 ( ortholog_one2one )
Dog_ ZFHX3 ( ortholog_one2one )
GuineaPig_ ZFHX3 ( ortholog_one2one )
Macaque_ ZFHX3 ( ortholog_one2one )
Mouse_ Zfhx3 ( ortholog_one2one )
Pig_ ZFHX3 ( ortholog_one2one )
Rat_ Zfhx3 ( ortholog_one2one )
Rabbit_ ZFHX3 ( ortholog_one2one )
OhnologsZFHX4
ParalogsLMX1B, LHX1, LHX6, CRIP3, ZFHX4, CRIP1, LHX5, FHL1, LMO3, LMO1, LHX4, CRIP2, LHX9, LMO2, LHX8, LMX1A, LHX3, LMO4, ZFHX2, LHX2
TissueNA
Tissue SpecificityNot found in normal gastric mucosa but found in gastric carcinoma cells (at protein level). Expression is higher in ER-positive breast tumors than ER-negative breast tumors (at protein level). {ECO:0000269|PubMed:17330845, ECO:0000269|PubMed:20599712, ECO:0000269|PubMed:20720010, ECO:0000269|PubMed:22452784}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2DA1  (NMR  -  )  2DA2  (NMR  -  )  2DA3  (NMR  -  ) 
DBSNP rs7193297  rs58480263  rs16971436  rs2073852  rs4788682  rs2213978  rs8044440 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:20599712, ECO:0000269|PubMed:24651376}. Cytoplasm {ECO:0000269|PubMed:20599712}. Note=Translocates from the cytoplasm to the nucleus following TGF-beta stimulation. Expressed in nuclear body (NB)-like dots in the nucleus some of which overlap or closely associate with PML body. {ECO:0000269|PubMed:20599712, ECO:0000269|PubMed:24651376}.
Mouse PG classificationNA
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