| Gene Information | |
|---|---|
| Gene Name | MMP16 |
| Organism | Homo sapiens (Human) |
| Gene Length | 607 |
| Protein Names | Matrix metalloproteinase-16 (MMP-16) (EC 3.4.24.-) (MMP-X2) (Membrane-type matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3) (Membrane-type-3 matrix metalloproteinase) (MT3-MMP) (MT3MMP) |
| Target Name | matrix metalloproteinase-16 |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000156103 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P51512 |
| Gene Card | MMP16 |
| Uniprot ID | P51512 |
| Pfam | PF11857; PF00045; PF00413; PF01471 |
| In ASD | no |
| Allosteric Prediction | no (-0.340634993) |
| Ortholog in Animals | Alpaca_ MMP16 ( ortholog_one2one ) Dog_ MMP16 ( ortholog_one2one ) GuineaPig_ MMP16 ( ortholog_one2one ) Macaque_ MMP16 ( ortholog_one2one ) Mouse_ Mmp16 ( ortholog_one2one ) Pig_ MMP16 ( ortholog_one2one ) Rat_ Mmp16 ( ortholog_one2one ) Rabbit_ MMP16 ( ortholog_one2one ) |
| Ohnologs | MMP2, MMP15, MMP8, MMP19, MMP24, MMP20, MMP13, MMP3, MMP14, MMP10, MMP1 |
| Paralogs | MMP24, MMP21, MMP14, MMP2, MMP1, MMP19, MMP23B, MMP10, MMP9, MMP12, MMP15, MMP27, MMP17, MMP25, MMP28, MMP13, MMP7, MMP20, MMP26, HPX, MMP8, MMP3, MMP11 |
| Tissue | NA |
| Tissue Specificity | Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1RM8 (X-ray 1.80A ) |
| DBSNP | NA |
| Subcellular location [CC] | [Isoform Long]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}; Extracellular side {ECO:0000305}. Note=Localized at the cell surface of melanoma cells.; [Isoform Short]: Secreted, extracellular space, extracellular matrix. Cell surface. Note=Localized at the cell surface of melanoma cells. |
| Mouse PG classification | NA |
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