| Gene Information | |
|---|---|
| Gene Name | GRB14 |
| Organism | Homo sapiens (Human) |
| Gene Length | 540 |
| Protein Names | Growth factor receptor-bound protein 14 (GRB14 adapter protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000115290 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q14449 |
| Gene Card | GRB14 |
| Uniprot ID | Q14449 |
| Pfam | PF08947; PF00169; PF00788; PF00017 |
| In ASD | no |
| Allosteric Prediction | yes (0.061938561) |
| Ortholog in Animals | Alpaca_ GRB14 ( ortholog_one2one ) Dog_ GRB14 ( ortholog_one2one ) GuineaPig_ GRB14 ( ortholog_one2one ) Macaque_ GRB14 ( ortholog_one2one ) Mouse_ Grb14 ( ortholog_one2one ) Pig_ GRB14 ( ortholog_one2one ) Rat_ Grb14 ( ortholog_one2one ) Rabbit_ GRB14 ( ortholog_one2one ) |
| Ohnologs | GRB10, GRB7 |
| Paralogs | APBB1IP, GRB7, RAPH1, GRB10 |
| Tissue | adrenal.gland, cortex.of.kidney, liver, testis |
| Tissue Specificity | Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.028571(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2AUG (X-ray 2.30A ) 2AUH (X-ray 3.20A ) 4K81 (X-ray 2.40A ) |
| DBSNP | rs61748245 rs144301087 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15210700, ECO:0000269|PubMed:19648926}. Endosome membrane {ECO:0000269|PubMed:15210700, ECO:0000269|PubMed:19648926}; Peripheral membrane protein {ECO:0000269|PubMed:15210700, ECO:0000269|PubMed:19648926}. Note=Upon insulin stimulation, translocates to the plasma membrane. {ECO:0000269|PubMed:15210700, ECO:0000269|PubMed:19648926}. |
| Mouse PG classification | NA |
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