Gene Information
Gene NamePANK2
OrganismHomo sapiens (Human)
Gene Length570
Protein NamesPantothenate kinase 2, mitochondrial (hPanK2) (EC 2.7.1.33) (Pantothenic acid kinase 2) [Cleaved into: Pantothenate kinase 2, mitochondrial intermediate form (iPanK2); Pantothenate kinase 2, mitochondrial mature form (mPanK2)]
Target NameNA
Target TypeNA
Gene Age987 ( ENSG00000125779 )
Evolutionary StageEukaryota
AlphaFoldDBQ9BZ23
Gene CardPANK2
Uniprot IDQ9BZ23
PfamPF03630
In ASDyes
Allosteric Predictionyes (0.951689195)
Ortholog in AnimalsAlpaca_ PANK2 ( ortholog_one2one )
Dog_ PANK2 ( ortholog_one2one )
Macaque_ PANK2 ( ortholog_one2one )
Mouse_ Pank2 ( ortholog_one2one )
Pig_ PANK2 ( ortholog_one2one )
Rat_ Pank2 ( ortholog_one2one )
Rabbit_ PANK2 ( ortholog_one2one )
OhnologsPANK3, PANK1
ParalogsPANK4, PANK3, PANK1
TissueNA
Tissue SpecificityExpressed in the brain (at protein level) (PubMed:15659606, PubMed:17825826). Ubiquitous (PubMed:11479594). Highly expressed in the testis (PubMed:17825826). Expressed in the umbilical vein endothelial cells (HUVEC) (PubMed:30221726). {ECO:0000269|PubMed:11479594, ECO:0000269|PubMed:15659606, ECO:0000269|PubMed:17825826, ECO:0000269|PubMed:30221726}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 5E26  (X-ray  2.14A  ) 
DBSNP rs71647827  rs71647828  rs3737084  rs765679726  rs137852965  rs137852961  rs137852966  rs1348762206  rs137852962  rs974575417  rs768230831  rs137852964  rs746484727  rs754521581  rs759223327  rs752078407  rs750176786  rs1064794317  rs1012947103  rs137852963  rs759332123  rs775459398  rs767653843  rs137852959  rs137852967  rs1324077575  rs41279408 
Subcellular location [CC][Isoform 1]: Mitochondrion {ECO:0000269|PubMed:12554685, ECO:0000269|PubMed:15659606, ECO:0000269|PubMed:17825826}. Mitochondrion intermembrane space {ECO:0000269|PubMed:23152917}. Nucleus {ECO:0000269|PubMed:23152917}. Note=Localizes predominantly to the mitochondria and to a lesser extent to the nucleus. Found in both the mitochondria and the nucleus throughout the cell cycle, with the exception of the G2/M phase when it is restricted to mitochdondria. {ECO:0000269|PubMed:23152917}.;
[Isoform 2]: Cytoplasm {ECO:0000305}.;
[Isoform 3]: Cytoplasm {ECO:0000269|PubMed:12554685, ECO:0000305}.;
[Isoform 4]: Cytoplasm {ECO:0000305}.
Mouse PG classificationNA
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