Gene Information
Gene NameMGARP
OrganismHomo sapiens (Human)
Gene Length240
Protein NamesProtein MGARP (Corneal endothelium-specific protein 1) (CESP-1) (Hypoxia up-regulated mitochondrial movement regulator protein) (Mitochondria-localized glutamic acid-rich protein) (Ovary-specific acidic protein)
Target NameNA
Target TypeNA
Gene Age544 ( ENSG00000137463 )
Evolutionary StageVertebrata
AlphaFoldDBQ8TDB4
Gene CardMGARP
Uniprot IDQ8TDB4
PfamPF14962
In ASDno
Allosteric Predictionno (-0.710474679)
Ortholog in AnimalsAlpaca_ MGARP ( ortholog_one2one )
Dog_ MGARP ( ortholog_one2one )
Macaque_ MGARP ( ortholog_one2one )
Mouse_ Mgarp ( ortholog_one2one )
Pig_ MGARP ( ortholog_one2one )
Rat_ Mgarp ( ortholog_one2one )
Rabbit_ MGARP ( ortholog_one2one )
OhnologsNA
ParalogsNA
Tissueadrenal.gland, ovary
Tissue SpecificityExpressed in the brain, adrenal gland and corneal endothelium (CE). Expressed in steroid-producing cells of the ovary and testis (at protein level). Expressed in steroid-producing cells of the ovary and testis. Weakly expressed in placenta. Expressed in corneal endothelial cells. {ECO:0000269|PubMed:12036975, ECO:0000269|PubMed:12770732, ECO:0000269|PubMed:16565373, ECO:0000269|PubMed:19325000, ECO:0000269|PubMed:19528298}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs3208941 
Subcellular location [CC]Mitochondrion {ECO:0000269|PubMed:16565373, ECO:0000269|PubMed:21447634}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q8VI64};
Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q8VI64};
Cytoplasmic side {ECO:0000250|UniProtKB:Q8VI64}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q8VI64};
Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q8VI64};
Cytoplasmic side {ECO:0000250|UniProtKB:Q8VI64}. Note=Colocalizes with RHOT1, RHOT2, TRAK1 and TRAK2 at the mitochondrion. {ECO:0000250|UniProtKB:Q8VI64}.
Mouse PG classificationNA
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